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. 1978 Oct;64(2):167–171. doi: 10.1111/j.1476-5381.1978.tb17286.x

Antidiuretic effect of morphine in the rat: tolerance and physical dependence.

F Huidobro
PMCID: PMC1668303  PMID: 568501

Abstract

1 Injection of rats with morphine or methadone, before they received a water load equivalent to 5% of their body weight, produced a dose-dependent antidiuretic effect. Following the antidiuresis, urine was eliminated with kinetics similar to control untreated rats. 2 The antidiuretic effect of morphine or methadone was blocked by naloxone administered before the opiate, or reversed when given after the opiate. 3 Rats implanted with morphine pellets developed a marked degree of tolerance to the antidiuretic effect of morphine. Tolerance was also obtained on injection of three daily doses of morphine or methadone over two days. 4 Withdrawal symptoms were precipitated by naloxone in rats implanted with pellets of morphine; under these conditions the animals showed a marked reduction in urine production as compared to naive rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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