Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1978 Oct;64(2):285–292. doi: 10.1111/j.1476-5381.1978.tb17302.x

The influence of sodium and potassium supplements on the diuretic responses to frusemide administration in normal subjects.

R A Branch, E Cole, C E Horth, L Jackson, L E Ramsay, J Shelton
PMCID: PMC1668306  PMID: 708998

Abstract

1 Twelve normal subjects received (1) normal diet, (2) normal diet with 100 mmol supplementary sodium chloride and (3) normal diet with 96 mmol supplementary potassium chloride, each for 10 days, in a balanced cross-over study according to a Latin Square design. At the end of each study period, the subjects received 80 mg frusemide orally. Each study period was separated from the other by 10 days. 2 Changes in urinary electrolyte excretion occurred within the first four days of each dietary period then remained constant, with significant differences in urinary Na/K ratio between the dietary regimes. 3 Between-subject correlations, using the mean values over the three study periods, demonstrated significant associations between plasma uric acid and urinary Na/K ratio and between plasma prolactin and urinary potassium excretion. 4 Urinary potassium excretion and Na/K ratio following frusemide were influenced significantly by alteration of diet but there was no change in sodium excretion. 5 Between-subject correlations of pretreatment variables with diuretic response, using the mean values over the three study periods, demonstrated significant associations between both pretreatment urinary Na/K ratio and plasma uric acid and respectively the urinary potassium excretion and urinary Na/K ratio in response to frusemide. 6 While the response to frusemide was altered by short-term changes in dietary sodium and potassium, the difference was less than expected from observations in two populations with customary diets differing in similar manner.

Full text

PDF
285

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Auty R., Branch R. A., Cole E. N., Levine D., Ramsay L. Prolactin, diuretics and urinary electrolytes in normal subjects. J Endocrinol. 1976 Aug;70(2):173–181. doi: 10.1677/joe.0.0700173. [DOI] [PubMed] [Google Scholar]
  2. Branch R. A., Read P. R., Levine D., Elst E. V., Shelton J., Rupp W., Ramsay L. E. Furosemide and bumetanide: a study of responses in normal English and German subjects. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):538–545. doi: 10.1002/cpt1976195part1538. [DOI] [PubMed] [Google Scholar]
  3. Cole E. N., Boyns A. R. Radioimmunoassay for human pituitary prolactin, using antiserum against an extract of human amniotic fluid. Horm Res. 1973;4(5):261–273. doi: 10.1159/000178313. [DOI] [PubMed] [Google Scholar]
  4. Grantham J. J., Kurg M. B., Obloff J. The nature of transtubular Na and K transport in isolated rabbit renal collecting tubules. J Clin Invest. 1970 Oct;49(10):1815–1826. doi: 10.1172/JCI106399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gross J. B., Imai M., Kokko J. P. A functional comparison of the cortical collecting tubule and the distal convoluted tubule. J Clin Invest. 1975 Jun;55(6):1284–1294. doi: 10.1172/JCI108048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Horrobin D. F., Lloyd I. J., Lipton A., Burstyn P. G., Durkin N., Muiruri K. L. Actions of prolactin on human renal function. Lancet. 1971 Aug 14;2(7720):352–354. doi: 10.1016/s0140-6736(71)90065-1. [DOI] [PubMed] [Google Scholar]
  7. Levine D., Ramsay L., Auty R., Branch R., Tidd M. Antagonism of endogenous mineralocorticoids in normal subjects by prorenoate potassium and spironolactone. Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):381–386. doi: 10.1007/BF00606552. [DOI] [PubMed] [Google Scholar]
  8. Nishi H. H. Determination of uric acid. An adaptation of the Archibald method on the autoanalyzer. Clin Chem. 1967 Jan;13(1):12–18. [PubMed] [Google Scholar]
  9. Ramsay L. E., Auty R. M., Horth C. E., Levine D., Shelton J. R., Branch R. A. Plasma uric acid concentration related to the urinary excretion of aldosterone and of electrolytes in normal subjects. Clin Sci Mol Med. 1975 Dec;49(6):613–616. doi: 10.1042/cs0490613. [DOI] [PubMed] [Google Scholar]
  10. Ramsay L. E., Hessian P., Tidd M. J. Bioassay of aldosterone antagonists in normal human subjects: a relationship between the level of plasma uric acid before treatment and apparent drug responses. Br J Clin Pharmacol. 1975 Jun;2(3):271–276. doi: 10.1111/j.1365-2125.1975.tb01587.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ramsay L. E., Shelton J. R., Harrison I. R. Plasma uric acid and spironolactone response in healthy subjects. Br J Clin Pharmacol. 1977 Apr;4(2):247–249. doi: 10.1111/j.1365-2125.1977.tb00706.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ramsay L. E., Tidd M. J., Auty R. M., Levine D., Branch R. A. A relationship between plasma uric acid concentration and the apparent response to frusemide in normal subjects. Br J Clin Pharmacol. 1975 Aug;2(4):361–362. doi: 10.1111/j.1365-2125.1975.tb02786.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rocha A. S., Kokko J. P. Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport. J Clin Invest. 1973 Mar;52(3):612–623. doi: 10.1172/JCI107223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Steele T. H. Evidence for altered renal urate reabsorption during changes in volume of the extracellular fluid. J Lab Clin Med. 1969 Aug;74(2):288–299. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES