Abstract
When guanethidine was applied to rabbit ventricular slices at 37 degrees C for an initial 30 min incubation period, doses of 4 X 10(-5) and 8 X 10(-5) M irreversibly inhibited increases in efflux of noradrenaline induced by the subsequent reduction of external sodium concentrations to 18 mM. This inhibition was prevented if the temperature was reduced to 0 degrees C during the drug application period. Guanethidine transported into adrenergic nerve endings appears to increase permeability to Na+, thereby leading to the reduction in efflux.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANTON A. H., SAYRE D. F. A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. J Pharmacol Exp Ther. 1962 Dec;138:360–375. [PubMed] [Google Scholar]
- BOURA A. L., GREEN A. F. ADRENERGIC NEURONE BLOCKING AGENTS. Annu Rev Pharmacol. 1965;5:183–212. doi: 10.1146/annurev.pa.05.040165.001151. [DOI] [PubMed] [Google Scholar]
- Gulati O. D., Jaykar S. Factors affecting the action of guanethidine on adrenergic neurones. Br J Pharmacol. 1971 Jul;42(3):352–363. doi: 10.1111/j.1476-5381.1971.tb07119.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hosotani T., Misu Y. Sodium sensitive active transport of bretylium into adrenergic neurons for the development of blockade in rabbit ileum. Arch Int Pharmacodyn Ther. 1977 Apr;226(2):235–245. [PubMed] [Google Scholar]
- Kubo T., Misu Y. Mode of action of guanethidine on adrenergic neurons and its dependence on sodium. Jpn J Pharmacol. 1974 Apr;24(2):307–318. doi: 10.1254/jjp.24.307. [DOI] [PubMed] [Google Scholar]
- Misu Y., Nishio H. Action of guanethidine on rabbit atrial membranes. Br J Pharmacol. 1978 May;63(1):17–23. doi: 10.1111/j.1476-5381.1978.tb07769.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Misu Y., Nishio H., Hosotani T., Hamano S. A new guanidine derivative: dissociation of the adrenergic neuron blocking activity from local anesthetic activity. Jpn J Pharmacol. 1976 Jun;26(3):367–375. doi: 10.1254/jjp.26.367. [DOI] [PubMed] [Google Scholar]