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. 1979 Jan;65(1):43–51. doi: 10.1111/j.1476-5381.1979.tb17332.x

Effects of noradrenaline and carbachol on temperature regulation of rats.

S Poole, J D Stephenson
PMCID: PMC1668465  PMID: 760890

Abstract

1 Noradrenaline (0.2 to 20 micrograms) and carbachol (0.1 to 1 microgram) injected into the preoptic/anterior hypothalamic area, evoked dose-dependent falls in core temperature at all sites tested, followed in most experiments by delayed increases that were not dose-related. Muscarine (0.1 to 10 microgram) produced effects similar to those evoked by carbachol. 2 These falls in core temperature were associated with increases in tail temperature, locomotor activity and CO2 elimination (a measure of metabolic rate). 3 The temperature responses to noradrenaline (10 microgram) and to carbachol (1 microgram) were antagonized by intrahypothalamic injections of phentolamine (10 microgram) and atropine (1 microgram), respectively. 4 Analysis of the temperature responses and their respective latencies indicates that carbachol-induced hypothermia was mediated by cholinoceptors in the anterior hypothalamus, whereas hypothermia after noradrenaline was mediated by adrenoceptors throughout the preoptic/anterior hypothalamic area. 5 Vasodilatation of the tail blood vessels contributed significantly to the hypothermia evoked by carbachol, and to that evoked by injections of noradrenaline into the anterior hypothalamus. 6 Hypothermia induced by noradrenaline injection into the preoptic area, was mediated by effector mechanisms additional to non-evaporative heat loss.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avery D. D. Intrahypothalamic adrenergic and cholinergic injection effects on temperature and ingestive behavior in the rat. Neuropharmacology. 1971 Nov;10(6):753–763. doi: 10.1016/0028-3908(71)90090-6. [DOI] [PubMed] [Google Scholar]
  2. BIRNIE J. H., GRAYSON J. Observations on temperature distribution and liver blood flow in the rat. J Physiol. 1952 Feb;116(2):189–201. doi: 10.1113/jphysiol.1952.sp004699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beckman A. L. Effect of intrahypothalamic norepinephrine on thermoregulatory responses in the rat. Am J Physiol. 1970 Jun;218(6):1596–1604. doi: 10.1152/ajplegacy.1970.218.6.1596. [DOI] [PubMed] [Google Scholar]
  4. Bligh J., Cottle W. H., Maskrey M. Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits. J Physiol. 1971 Jan;212(2):377–392. doi: 10.1113/jphysiol.1971.sp009330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brezenoff H. E. Cardiovascular responses to intrahypothalamic injections of carbachol and certain cholinesterase inhibitors. Neuropharmacology. 1972 Sep;11(5):637–644. doi: 10.1016/0028-3908(72)90072-x. [DOI] [PubMed] [Google Scholar]
  6. Briese E., De Quijada M. G. Colonic temperature of rats during handling. Acta Physiol Lat Am. 1970;20(2):97–102. [PubMed] [Google Scholar]
  7. Crawshaw L. I. Effect of intracranial acetylcholine injection on thermoregulatory responses in the rat. J Comp Physiol Psychol. 1973 Apr;83(1):32–35. doi: 10.1037/h0034252. [DOI] [PubMed] [Google Scholar]
  8. Kirkpatrick W. E., Lomax P., Jenden D. J. The effect of muscarinic agents on the thermoregulatory centers in the rat. Proc West Pharmacol Soc. 1967;10:51–55. [PubMed] [Google Scholar]
  9. Kirkpatrick W. E., Lomax P. Temperature changes following iontophoretic injection of acetylcholine into the rostral hypothalamus of the rat. Neuropharmacology. 1970 May;9(3):195–202. doi: 10.1016/0028-3908(70)90067-5. [DOI] [PubMed] [Google Scholar]
  10. Kirkpatrick W. E., Lomax P. The effect of atropine on the body temperature of the rat following systemic and intracerebral injection. Life Sci. 1967 Nov 1;6(21):2273–2278. doi: 10.1016/0024-3205(67)90035-5. [DOI] [PubMed] [Google Scholar]
  11. Lomax P., Foster R. S., Kirkpatrick W. E. Cholinergic and adrenergic interactions in the thermoregulatory centers of the rat. Brain Res. 1969 Oct;15(2):431–438. doi: 10.1016/0006-8993(69)90165-6. [DOI] [PubMed] [Google Scholar]
  12. Martin G. E., Pryzbylik A. T., Spector N. H. Restraint alters the effects of morphine and heroin on core temperature in the rat. Pharmacol Biochem Behav. 1977 Nov;7(5):463–469. doi: 10.1016/0091-3057(77)90215-5. [DOI] [PubMed] [Google Scholar]
  13. Poole S., Stephenson J. D. Body temperature regulation and thermoneutrality in rats. Q J Exp Physiol Cogn Med Sci. 1977 Apr;62(2):143–149. doi: 10.1113/expphysiol.1977.sp002384. [DOI] [PubMed] [Google Scholar]
  14. Poole S., Stephenson J. D. Core temperature: some shortcomings of rectal temperature measurements. Physiol Behav. 1977 Feb;18(2):203–205. doi: 10.1016/0031-9384(77)90122-6. [DOI] [PubMed] [Google Scholar]
  15. Poole S., Stephenson J. D. Effects of intrahypothalamic injections of noradrenaline and carbachol on core temperature of unrestrained rats [proceedings]. Br J Pharmacol. 1977 Mar;59(3):482P–483P. [PMC free article] [PubMed] [Google Scholar]
  16. Struyker Boudier H. A., Smeets G. W., Brouwer G. M., van Rossum J. M. Hypothalamic alpha adrenergic receptors in cardiovascular regulation. Neuropharmacology. 1974 Sep;13(9):837–846. doi: 10.1016/0028-3908(74)90039-2. [DOI] [PubMed] [Google Scholar]
  17. Veale W. L., Whishaw I. Q. Body temperature responses at different ambient temperatures following injections of prostaglandin E1 and noradrenaline into the brain. Pharmacol Biochem Behav. 1976 Feb;4(2):143–150. doi: 10.1016/0091-3057(76)90006-x. [DOI] [PubMed] [Google Scholar]

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