Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1979 Jan;65(1):7–13. doi: 10.1111/j.1476-5381.1979.tb17327.x

Morphine depression and tolerance of nerve-induced parotid secretion.

S R Bowen, F G Carpenter
PMCID: PMC1668469  PMID: 760892

Abstract

1 The nerve-induced secretion produced by the rat parotid gland is proportional to the frequency of stimulation. Morphine decreased the flow rate during stimulation at 2.5 and 5 Hz, but not at 20 Hz. This frequency-dependent action of morphine and was partially reversed by naloxone. 2 The secretion produced by the rat parotid gland during an intravenous infusion of acetylcholine was not diminished by morphine. Therefore, the action of morphine on nerve-induced secretion is most probably on the motor nerve terminals, which release acetylcholine. 3 Animals that had been implanted with morphine base pellets tolerated 4 times as much morphine as controls; after 6 days the minute ventilation was less depressed by graded doses of morphine than non-implanted controls. 4 Nerve-induced secretion in morphine-implanted animals was less depressed by morphine than control animals 6 and 24 h after the pellets were removed. The flow rates in the 6 h group treated with morphine were greater after naloxone than control (precipitated withdrawal) but at 24 h when withdrawal symptoms were no longer evident, naloxone produced only a slight reversal.

Full text

PDF
7

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTLETT D., Jr, TENNEY S. M. Tissue gas tensions in experimental anemia. J Appl Physiol. 1963 Jul;18:734–738. doi: 10.1152/jappl.1963.18.4.734. [DOI] [PubMed] [Google Scholar]
  2. BELESLIN D., POLAK R. L. DEPRESSION BY MORPHINE AND CHLORALOSE OF ACETYLCHOLINE RELEASE FROM THE CAT'S BRAIN. J Physiol. 1965 Apr;177:411–419. doi: 10.1113/jphysiol.1965.sp007600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blumberg H., Dayton H. B., Wolf P. S. Counteraction of narcotic antagonist analgesics by the narcotic antagonist Naloxone. Proc Soc Exp Biol Med. 1966 Dec;123(3):755–758. doi: 10.3181/00379727-123-31595. [DOI] [PubMed] [Google Scholar]
  4. CAIRNIE A. B., KOSTERLITZ H. W., TAYLOR D. W. Effect of morphine on some sympathetically innervated effectors. Br J Pharmacol Chemother. 1961 Dec;17:539–551. doi: 10.1111/j.1476-5381.1961.tb01141.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DEHAVEN K. E., CARPENTER F. G. INTERACTION BETWEEN CO2 AND CITRATE IONS IN MEDULLARY RETICULAR FORMATION. Am J Physiol. 1964 Aug;207:298–302. doi: 10.1152/ajplegacy.1964.207.2.298. [DOI] [PubMed] [Google Scholar]
  6. Gibson R. D., Tingstad J. E. Formulation of a morphine implantation pellet suitable for tolerance-physical dependence studies in mice. J Pharm Sci. 1970 Mar;59(3):426–427. doi: 10.1002/jps.2600590338. [DOI] [PubMed] [Google Scholar]
  7. Goldstein A., Schulz R. Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Br J Pharmacol. 1973 Aug;48(4):655–666. doi: 10.1111/j.1476-5381.1973.tb08254.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greenberg R., Kosterlitz H. W., Waterfield A. A. The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus-longitudinal muscle preparation of the ileum. Br J Pharmacol. 1970 Nov;40(3):553P–554P. [PMC free article] [PubMed] [Google Scholar]
  9. Henderson G., Hughes J., Kosterlitz H. W. A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. Br J Pharmacol. 1972 Dec;46(4):764–766. doi: 10.1111/j.1476-5381.1972.tb06901.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jhamandas K., Phillis J. W., Pinsky C. Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat. Br J Pharmacol. 1971 Sep;43(1):53–66. doi: 10.1111/j.1476-5381.1971.tb07156.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KOSTERLITZ H. W., TAYLOR D. W. The effect of morphine on vagal inhibition of the heart. Br J Pharmacol Chemother. 1959 Jun;14(2):209–214. doi: 10.1111/j.1476-5381.1959.tb01385.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MASLAND W. S., YAMAMOTO W. S. Abolition of ventilatory response to inhaled CO2 by neurological lesions. Am J Physiol. 1962 Nov;203:789–795. doi: 10.1152/ajplegacy.1962.203.5.789. [DOI] [PubMed] [Google Scholar]
  13. PATON W. D. CHOLINERGIC TRANSMISSION AND ACETYLCHOLINE OUTPUT. Can J Biochem Physiol. 1963 Dec;41:2637–2653. [PubMed] [Google Scholar]
  14. PATON W. D. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother. 1957 Mar;12(1):119–127. doi: 10.1111/j.1476-5381.1957.tb01373.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schneyer C. A., Hall H. D. Comparison of rat salivas evoked by auriculo-temporal and pilocarpine stimulation. Am J Physiol. 1965 Sep;209(3):484–488. doi: 10.1152/ajplegacy.1965.209.3.484. [DOI] [PubMed] [Google Scholar]
  16. Sharkawi M., Schulman M. P. Inhibition by morphine of the release of [14c]acetylcholine from rat brain cortex slices. J Pharm Pharmacol. 1969 Aug;21(8):546–547. doi: 10.1111/j.2042-7158.1969.tb08311.x. [DOI] [PubMed] [Google Scholar]
  17. Woodruff C. R., Carpenter F. G. Actions of catecholamines and physostigmine on rat parotid salivary secretion. Am J Physiol. 1973 Dec;225(6):1449–1453. doi: 10.1152/ajplegacy.1973.225.6.1449. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES