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. 1979 Jan;65(1):139–146. doi: 10.1111/j.1476-5381.1979.tb17342.x

The effects of opiate receptor agonists and antagonists on the stress-induced secretion of corticosterone in mice.

A Gibson, M Ginsburg, M Hall, S L Hart
PMCID: PMC1668477  PMID: 216447

Abstract

1 Intraperitoneal administration of normorphine, morphine or naloxone or exposure to ether vapour for 1 min, elevated plasma corticosteroid concentrations in mice. 2 Injection of saline or exposure to ether vapour rendered mice less sensitive to a subsequent exposure to ether vapour 15 min later. 3 Treatment with normorphine (50 mg/kg) potentiated the corticosteroid response to ether stress whilst pentazocine (20 mg/kg), naltrexone (10 mg/kg), morphine (24 mg/kg), levorphanol (20 mg/kg) and naloxone (50 mg/kg) prevented the stress-induced elevation of plasma corticosteroids. 4 Both naloxone and morphine inhibited the potentiation by normorphine of the response to ether, the dose of naloxone required being higher than that for inhibition of normorphine analgesia. 5 It is concluded that endogenous opioid peptides may be involved in the control of the response to ether stress in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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