Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1979 Feb;65(2):193–196. doi: 10.1111/j.1476-5381.1979.tb07818.x

A comparative study of the action of frusemide and methyclothiazide on renin release by rat kidney slices and the interaction with indomethacin.

E Desaulles, J Schwartz
PMCID: PMC1668622  PMID: 760897

Abstract

1 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. 2 Frusemide at concentrations of 1.5 and 7.5 mmol/l produced significant increases in renin release but had no effect at 0.15 mmol/l. 3 Methyclothiazide in a similar concentration range did not increase renin release; instead, at the highest concentration used, methyclothiazide (3.5 mmol/l) inhibited renin release. 4 Indomethacin (25 mumol/l) did not inhibit the increase of renin induced by frusemide. 5 Our limited study in vitro is consistent with the findings of other workers who have shown in vivo, in the absence of systemic electrolyte depletion, that only "loop diuretics" increase renin secretion. Under our experimental conditions, it is suggested that frusemide exerts a direct action either upon the epithelioid cells or upon the macula densa since the renal prostaglandin system does not intervene.

Full text

PDF
193

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooke C. R., Brown T. C., Zacherle B. J., Walker W. G. The effect of altered sodium concentration in the distal nephron segments on renin release. J Clin Invest. 1970 Sep;49(9):1630–1638. doi: 10.1172/JCI106380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Desaulles E., Forler C., Velly J., Schwartz J. Effect of catecholamines on renin release in vitro. Biomedicine. 1975 Sep;22(5):433–439. [PubMed] [Google Scholar]
  3. Desaulles E., Miesch F., Schwartz J. Evidence for the participation of beta1-adrenoceptors in isoprenaline-induced renin release from rat kidny slices in vitro. Br J Pharmacol. 1978 Jul;63(3):421–425. doi: 10.1111/j.1476-5381.1978.tb07793.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Desaulles E., Schwartz J. Action du furosémide sur la libération de rénine in vitro. C R Acad Sci Hebd Seances Acad Sci D. 1974 Sep 30;279(14):1221–1224. [PubMed] [Google Scholar]
  5. FORD R. V. Clinical-pharmacologic investigation of methyclothiazide, a new oral diuretic. Curr Ther Res Clin Exp. 1960 Sep;2:422–429. [PubMed] [Google Scholar]
  6. Frölich J. C., Hollifield J. W., Dormois J. C., Frölich B. L., Seyberth H., Michelakis A. M., Oates J. A. Suppression of plasma renin activity by indomethacin in man. Circ Res. 1976 Sep;39(3):447–452. doi: 10.1161/01.res.39.3.447. [DOI] [PubMed] [Google Scholar]
  7. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  8. Hook J. B., Bailie M. D. Release of vasoactive materials from the kidney by diuretics. J Clin Pharmacol. 1977 Oct;17(10 Pt 2):673–689. [PubMed] [Google Scholar]
  9. Imbs J. L., Desaulles E., Velly J., Bloch R., Schwartz J. Action du clopamide et de l'acide ethacrynique sur la sécrétion de rénine chez le chien. Pflugers Arch. 1972;331(4):294–306. doi: 10.1007/BF00592690. [DOI] [PubMed] [Google Scholar]
  10. Imbs J. L., Schmidt M., Velly J., Schwartz J. Comparison of the effect of two groups of diuretics on renin secretion in the anaesthetized dog. Clin Sci Mol Med. 1977 Feb;52(2):171–182. doi: 10.1042/cs0520171. [DOI] [PubMed] [Google Scholar]
  11. Larochelle P., Mikulic E., Ogilvie R. I. Effects of isoproterenol, diazoxide, ethacrynic acid, and furosemide on skeletal muscle vascular resistance. Can J Physiol Pharmacol. 1973 Mar;51(3):183–189. doi: 10.1139/y73-026. [DOI] [PubMed] [Google Scholar]
  12. Larsson C., Anggård E. Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney. Eur J Pharmacol. 1973 Jan;21(1):30–36. doi: 10.1016/0014-2999(73)90202-1. [DOI] [PubMed] [Google Scholar]
  13. Lyons H. J., Chruchhill P. C. Renin secretion from rat renal cortical cell suspensions. Am J Physiol. 1975 Jun;228(6):1835–1839. doi: 10.1152/ajplegacy.1975.228.6.1835. [DOI] [PubMed] [Google Scholar]
  14. Meng K. Mikropunktionsuntersuchungen über die saluretische Wirkung von Hydrochlorothiazid, Acetazolamid und Furosemid. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;257(3):355–371. [PubMed] [Google Scholar]
  15. Meyer P., Menard J., Papanicolaou N., Alexandre J. M., Devaux C., Milliez P. Mechanism of renin release following furosemide diuresis in rabbit. Am J Physiol. 1968 Oct;215(4):908–915. doi: 10.1152/ajplegacy.1968.215.4.908. [DOI] [PubMed] [Google Scholar]
  16. Oliw E., Kövér G., Larsson C., Anggård E. Reduction by indomethacin of furosemide effects in the rabbit. Eur J Pharmacol. 1976 Jul;38(1):95–100. doi: 10.1016/0014-2999(76)90205-3. [DOI] [PubMed] [Google Scholar]
  17. Ryan J. W., McKenzie J. K., Lee M. R. A rapid simple method for the assay of renin in rabbit plasma. Biochem J. 1968 Jul;108(4):679–685. doi: 10.1042/bj1080679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sirois P., Gagnon D. J. Release of prostaglandins from the rabbit renal medulla. Eur J Pharmacol. 1974 Sep;28(1):18–24. doi: 10.1016/0014-2999(74)90107-1. [DOI] [PubMed] [Google Scholar]
  19. Van Dongen R., Peart W. S. Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat. Br J Pharmacol. 1974 Jan;50(1):125–129. doi: 10.1111/j.1476-5381.1974.tb09599.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vander A. J., Carlson J. Mechanism of the effects of furosemide on renin secretion in anesthetized dogs. Circ Res. 1969 Aug;25(2):145–152. doi: 10.1161/01.res.25.2.145. [DOI] [PubMed] [Google Scholar]
  21. Vandongen R., Greenwood D. M. Stimulation of renin secretion by frusemide and diazoxide in the isolated rat kidney. Clin Sci Mol Med Suppl. 1976 Dec;3:101s–104s. doi: 10.1042/cs051101s. [DOI] [PubMed] [Google Scholar]
  22. Vandongen R. Intrarenal stimulation of renin secretion by frusemide in the isolated kidney of the rat. Br J Pharmacol. 1977 May;60(1):73–76. doi: 10.1111/j.1476-5381.1977.tb16749.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES