Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1979 Mar;65(3):357–359. doi: 10.1111/j.1476-5381.1979.tb07837.x

Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken.

H Anhut, K Brune, J C Frölich, B A Peskar
PMCID: PMC1668658  PMID: 570865

Abstract

An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D2(PGD2)E2 and F2 alpha and thromboxane B2 content by specific radioimmunoassays. We found that PGD2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE2. This finding was confirmed by gas chromatography-mass spectrometry. It is concluded that PGD2 should be considered as a possible mediator of acute inflammation.

Full text

PDF
357

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdel-Halim M. S., Hamberg M., Sjöquist B., Anggård E. Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain. Prostaglandins. 1977 Oct;14(4):633–643. doi: 10.1016/0090-6980(77)90190-3. [DOI] [PubMed] [Google Scholar]
  2. Anhut H., Peskar B. A., Bernauer W. Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):247–252. doi: 10.1007/BF00498818. [DOI] [PubMed] [Google Scholar]
  3. Anhut H., Peskar B. A., Wachter W., Gräbling B., Peskar B. M. Radioimmunological determination of prostaglandin D2 synthesis in human thrombocytes. Experientia. 1978 Nov 15;34(11):1494–1496. doi: 10.1007/BF01932373. [DOI] [PubMed] [Google Scholar]
  4. Brune K., Glatt M. The avian microcrystal arthritis. 3. Invasion and enzyme-release from leukocytes at the site of inflammation. Agents Actions. 1974 Apr;4(2):95–100. doi: 10.1007/BF01966817. [DOI] [PubMed] [Google Scholar]
  5. Flower R. J., Harvey E. A., Kingston W. P. Inflammatory effects of prostaglandin D2 in rat and human skin. Br J Pharmacol. 1976 Feb;56(2):229–233. doi: 10.1111/j.1476-5381.1976.tb07446.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Glatt M., Peskar B., Brune K. Leukocytes and prostaglandins in acute inflammation. Experientia. 1974 Nov 15;30(11):1257–1259. doi: 10.1007/BF01945171. [DOI] [PubMed] [Google Scholar]
  7. Hamberg M., Fredholm B. B. Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin. Biochim Biophys Acta. 1976 Apr 22;431(1):189–183. doi: 10.1016/0005-2760(76)90273-3. [DOI] [PubMed] [Google Scholar]
  8. Hamberg M., Samuelsson B. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc Natl Acad Sci U S A. 1973 Mar;70(3):899–903. doi: 10.1073/pnas.70.3.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kloeze J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta. 1969 Oct 28;187(3):285–292. doi: 10.1016/0005-2760(69)90001-0. [DOI] [PubMed] [Google Scholar]
  10. Kuehl F. A., Jr, Humes J. L., Egan R. W., Ham E. A., Beveridge G. C., Van Arman C. G. Role of prostaglandin endoperoxide PGG2 in inflammatory processes. Nature. 1977 Jan 13;265(5590):170–173. doi: 10.1038/265170a0. [DOI] [PubMed] [Google Scholar]
  11. Nishizawa E. E., Miller W. L., Gorman R. R., Bundy G. L., Svensson J., Hamberg M. Prostaglandin d2 as a potential antithrombotic agent. Prostaglandins. 1975 Jan;9(1):109–121. doi: 10.1016/s0090-6980(75)80122-5. [DOI] [PubMed] [Google Scholar]
  12. Nugteren D. H., Hazelhof E. Isolation and properties of intermediates in prostaglandin biosynthesis. Biochim Biophys Acta. 1973 Dec 20;326(3):448–461. doi: 10.1016/0005-2760(73)90145-8. [DOI] [PubMed] [Google Scholar]
  13. Peskar B. A., Glatt M., Anhut H., Brune K. Effect of imidazole on prostaglandin and thromboxane accumulation in urate arthritis. Eur J Pharmacol. 1978 Aug 15;50(4):437–441. doi: 10.1016/0014-2999(78)90150-4. [DOI] [PubMed] [Google Scholar]
  14. Smith J. B., Silver M. J., Ingerman C. M., Kocsis J. J. Prostaglandin D2 inhibits the aggregation of human platelets. Thromb Res. 1974 Sep;5(3):291–299. doi: 10.1016/0049-3848(74)90168-6. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES