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. 1991 Jun 8;302(6789):1361–1365. doi: 10.1136/bmj.302.6789.1361

Delaying childbearing: effect of age on fecundity and outcome of pregnancy.

B M van Noord-Zaadstra 1, C W Looman 1, H Alsbach 1, J D Habbema 1, E R te Velde 1, J Karbaat 1
PMCID: PMC1670055  PMID: 2059713

Abstract

OBJECTIVES--To study the age of the start of the fall (critical age) in fecundity; the probability of a pregnancy leading to a healthy baby taking into account the age of the woman; and, combining these results, to determine the age dependent probability of getting a healthy baby. DESIGN--Cohort study of all women who had entered a donor insemination programme. SETTING--Two fertility clinics serving a large part of The Netherlands. SUBJECTS--Of 1637 women attending for artificial insemination 751 fulfilled the selection criteria, being married to an azoospermic husband and nulliparous and never having received donor insemination before. MAIN OUTCOME MEASURES--The number of cycles before pregnancy (a positive pregnancy test result) or stopping treatment; and result of the pregnancy (successful outcome). RESULTS--Of the 751 women, 555 became pregnant and 461 had healthy babies. The fall in fecundity was estimated to start at around 31 years (critical age); after 12 cycles the probability of pregnancy in a woman aged greater than 31 was 0.54 compared with 0.74 in a woman aged 20.31. After 24 cycles this difference had decreased (probability of conception 0.75 in women greater than 31 and 0.85 in women 20.31). The probability of having a healthy baby also decreased--by 3.5% a year after the age of 30. Combining both these age effects, the chance of a woman aged 35 having a healthy baby was about half that of a woman aged 25. CONCLUSION--After the age of 31 the probability of conception falls rapidly, but this can be partly compensated for by continuing insemination for more cycles. In addition, the probability of an adverse pregnancy outcome starts to increase at about the same age.

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Selected References

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  1. Berkowitz G. S., Skovron M. L., Lapinski R. H., Berkowitz R. L. Delayed childbearing and the outcome of pregnancy. N Engl J Med. 1990 Mar 8;322(10):659–664. doi: 10.1056/NEJM199003083221004. [DOI] [PubMed] [Google Scholar]
  2. Bongaarts J. Infertility after age 30: a false alarm. Fam Plann Perspect. 1982 Mar-Apr;14(2):75–78. [PubMed] [Google Scholar]
  3. Emperaire J. C., Gauzere-Soumireu E., Audebert A. J. Female fertility and donor insemination. Fertil Steril. 1982 Jan;37(1):90–93. doi: 10.1016/s0015-0282(16)45983-2. [DOI] [PubMed] [Google Scholar]
  4. Harrison K. L., Breen T. M., Hennessey J. F., Hynes M. J., Keeping J. D., Kilvert G. T., DeAmbrosis P. J., Molloy D. Patient age and success in a human IVF programme. Aust N Z J Obstet Gynaecol. 1989 Aug;29(3 Pt 2):326–328. doi: 10.1111/j.1479-828x.1989.tb01755.x. [DOI] [PubMed] [Google Scholar]
  5. Howe G., Westhoff C., Vessey M., Yeates D. Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study. Br Med J (Clin Res Ed) 1985 Jun 8;290(6483):1697–1700. doi: 10.1136/bmj.290.6483.1697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lamb E. J., Hagen M., Pauker S. G. The mean interval to conception: a measure of utility for the analysis of decisions involving fertility. Am J Obstet Gynecol. 1989 Jun;160(6):1470–1478. doi: 10.1016/0002-9378(89)90872-7. [DOI] [PubMed] [Google Scholar]
  7. Menken J., Trussell J., Larsen U. Age and infertility. Science. 1986 Sep 26;233(4771):1389–1394. doi: 10.1126/science.3755843. [DOI] [PubMed] [Google Scholar]
  8. Rudman D., Feller A. G., Nagraj H. S., Gergans G. A., Lalitha P. Y., Goldberg A. F., Schlenker R. A., Cohn L., Rudman I. W., Mattson D. E. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990 Jul 5;323(1):1–6. doi: 10.1056/NEJM199007053230101. [DOI] [PubMed] [Google Scholar]
  9. Schwartz D., Mayaux M. J. Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS. N Engl J Med. 1982 Feb 18;306(7):404–406. doi: 10.1056/NEJM198202183060706. [DOI] [PubMed] [Google Scholar]
  10. Spira A. The decline of fecundity with age. Maturitas. 1988;Suppl 1:15–22. doi: 10.1016/0378-5122(88)90004-7. [DOI] [PubMed] [Google Scholar]
  11. Stein Z. A. A woman's age: childbearing and child rearing. Am J Epidemiol. 1985 Mar;121(3):327–342. doi: 10.1093/oxfordjournals.aje.a114004. [DOI] [PubMed] [Google Scholar]
  12. Yoshimura Y., Hosoi Y., Atlas S. J., Wallach E. E. Effect of clomiphene citrate on in vitro ovulated ova. Fertil Steril. 1986 Jun;45(6):800–804. doi: 10.1016/s0015-0282(16)49396-9. [DOI] [PubMed] [Google Scholar]

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