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. 1991 Sep 7;303(6802):553–556. doi: 10.1136/bmj.303.6802.553

Change in alcohol consumption and risk of death from all causes and from ischaemic heart disease.

N B Lazarus 1, G A Kaplan 1, R D Cohen 1, D J Leu 1
PMCID: PMC1670864  PMID: 1912885

Abstract

OBJECTIVE--To examine the association between alcohol consumption and mortality from all causes and from ischaemic heart disease with a focus on differentiating between long term abstainers and more recent non-drinkers. DESIGN--Cohort study of changes in alcohol consumption from 1965 to 1974 and mortality from all causes and ischaemic heart disease during 1974-84. SETTING--Population based study of adult residents of Alameda County, California. SUBJECTS--2225 women and 1845 men aged 35 and over in 1965. MAIN OUTCOME MEASURES--Alcohol consumption in 1964 and 1974 and mortality from all causes and from ischaemic heart disease during 1974-84. RESULTS--There was a significantly higher risk of death from all causes and from ischaemic heart disease in women who gave up drinking between 1965 and 1974 than in women who continued to drink (relative risk 1.72, 95% confidence interval 1.11 to 2.66, and 2.75, 1.44 to 5.23, for all causes and ischaemic heart disease respectively). A significant increase in risk was not seen in men who gave up drinking (1.32, 0.87 to 2.01, and 0.95, 0.41 to 2.20, respectively). Among men, long term abstainers compared with drinkers were at increased risk of death from all causes and from ischaemic heart disease, though the associations were not significant (1.40, 0.98 to 2.00, and 1.40, 0.76 to 2.58, for all causes and ischaemic heart disease respectively). CONCLUSION--Some of the increased risk of death from all causes and from ischaemic heart disease associated with not drinking in women seems to be accounted for by higher risks among those who gave up drinking. Men who are long term abstainers may also be at an increased risk of death. The heterogeneity of the non-drinking group should be considered when comparisons are made with drinkers.

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Selected References

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  1. Arellano M. G., Petersen G. R., Petitti D. B., Smith R. E. The California Automated Mortality Linkage System (CAMLIS). Am J Public Health. 1984 Dec;74(12):1324–1330. doi: 10.2105/ajph.74.12.1324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Belloc N. B., Arellano M. G. Computer record linkage on a survey population. Health Serv Rep. 1973 Apr;88(4):344–350. [PMC free article] [PubMed] [Google Scholar]
  3. Boffetta P., Garfinkel L. Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiology. 1990 Sep;1(5):342–348. doi: 10.1097/00001648-199009000-00003. [DOI] [PubMed] [Google Scholar]
  4. Camacho T. C., Kaplan G. A., Cohen R. D. Alcohol consumption and mortality in Alameda County. J Chronic Dis. 1987;40(3):229–236. doi: 10.1016/0021-9681(87)90158-5. [DOI] [PubMed] [Google Scholar]
  5. Castelli W. P., Doyle J. T., Gordon T., Hames C. G., Hjortland M. C., Hulley S. B., Kagan A., Zukel W. J. Alcohol and blood lipids. The cooperative lipoprotein phenotyping study. Lancet. 1977 Jul 23;2(8030):153–155. doi: 10.1016/s0140-6736(77)90176-3. [DOI] [PubMed] [Google Scholar]
  6. Colsher P. L., Wallace R. B. Is modest alcohol consumption better than none at all? An epidemiologic assessment. Annu Rev Public Health. 1989;10:203–219. doi: 10.1146/annurev.pu.10.050189.001223. [DOI] [PubMed] [Google Scholar]
  7. Dyer A. R., Stamler J., Paul O., Berkson D. M., Lepper M. H., McKean H., Shekelle R. B., Lindberg H. A., Garside D. Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies. Circulation. 1977 Dec;56(6):1067–1074. doi: 10.1161/01.cir.56.6.1067. [DOI] [PubMed] [Google Scholar]
  8. Dyer A. R., Stamler J., Paul O., Lepper M., Shekelle R. B., McKean H., Garside D. Alcohol consumption and 17-year mortality in the Chicago Western Electric Company study. Prev Med. 1980 Jan;9(1):78–90. doi: 10.1016/0091-7435(80)90060-2. [DOI] [PubMed] [Google Scholar]
  9. Ellison R. C. Cheers! Epidemiology. 1990 Sep;1(5):337–339. [PubMed] [Google Scholar]
  10. Frezza M., di Padova C., Pozzato G., Terpin M., Baraona E., Lieber C. S. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 1990 Jan 11;322(2):95–99. doi: 10.1056/NEJM199001113220205. [DOI] [PubMed] [Google Scholar]
  11. Jackson R., Scragg R., Beaglehole R. Alcohol consumption and risk of coronary heart disease. BMJ. 1991 Jul 27;303(6796):211–216. doi: 10.1136/bmj.303.6796.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Klatsky A. L., Friedman G. D., Siegelaub A. B. Alcohol consumption before myocardial infarction. Results from the Kaiser-Permanente epidemiologic study of myocardial infarction. Ann Intern Med. 1974 Sep;81(3):294–301. doi: 10.7326/0003-4819-81-3-294. [DOI] [PubMed] [Google Scholar]
  13. Marmot M. G., Rose G., Shipley M. J., Thomas B. J. Alcohol and mortality: a U-shaped curve. Lancet. 1981 Mar 14;1(8220 Pt 1):580–583. doi: 10.1016/s0140-6736(81)92032-8. [DOI] [PubMed] [Google Scholar]
  14. Meade T. W., Chakrabarti R., Haines A. P., North W. R., Stirling Y. Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Br Med J. 1979 Jan 20;1(6157):153–156. doi: 10.1136/bmj.1.6157.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Moore R. D., Pearson T. A. Moderate alcohol consumption and coronary artery disease. A review. Medicine (Baltimore) 1986 Jul;65(4):242–267. doi: 10.1097/00005792-198607000-00004. [DOI] [PubMed] [Google Scholar]
  16. Seeman T. E., Kaplan G. A., Knudsen L., Cohen R., Guralnik J. Social network ties and mortality among the elderly in the Alameda County Study. Am J Epidemiol. 1987 Oct;126(4):714–723. doi: 10.1093/oxfordjournals.aje.a114711. [DOI] [PubMed] [Google Scholar]
  17. Stampfer M. J., Colditz G. A., Willett W. C., Speizer F. E., Hennekens C. H. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988 Aug 4;319(5):267–273. doi: 10.1056/NEJM198808043190503. [DOI] [PubMed] [Google Scholar]
  18. Wannamethee G., Shaper A. G. Men who do not drink: a report from the British Regional Heart Study. Int J Epidemiol. 1988 Jun;17(2):307–316. doi: 10.1093/ije/17.2.307. [DOI] [PubMed] [Google Scholar]
  19. Yano K., Reed D. M., McGee D. L. Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Relationship to biologic and lifestyle characteristics. Am J Epidemiol. 1984 May;119(5):653–666. doi: 10.1093/oxfordjournals.aje.a113787. [DOI] [PubMed] [Google Scholar]
  20. Yano K., Rhoads G. G., Kagan A. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. N Engl J Med. 1977 Aug 25;297(8):405–409. doi: 10.1056/NEJM197708252970801. [DOI] [PubMed] [Google Scholar]

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