Abstract
Twenty-one patients had serial samples of blood taken before, during, and after operation for the measurement of plasma glucagon, plasma insulin, and blood glucose concentrations. A significant rise in plasma glucagon level was noted during the operation. In contrast the plasma insulin concentration fell during the operation and rose in the postoperative period despite hyperglycaemia during and after the operation. These findings show that hyperglucagonaemia is a physiological consequence of a surgical operation and that the relationship of plasms glucagon to plasma insulin is complex.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albano J. D., Ekins R. P., Maritz G., Turner R. C. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 1972 Jul;70(3):487–509. doi: 10.1530/acta.0.0700487. [DOI] [PubMed] [Google Scholar]
- Allison S. P., Prowse K., Chamberlain M. J. Failure of insulin response to glucose load during operation and after myocardial infarction. Lancet. 1967 Mar 4;1(7488):478–481. doi: 10.1016/s0140-6736(67)91097-5. [DOI] [PubMed] [Google Scholar]
- Bloom S. R., Edwards A. V., Vaughan N. J. The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol. 1973 Sep;233(2):457–466. doi: 10.1113/jphysiol.1973.sp010317. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cherrington A., Vranic M., Fono P., Kovacevic N. Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions. Can J Physiol Pharmacol. 1972 Oct;50(10):946–954. doi: 10.1139/y72-137. [DOI] [PubMed] [Google Scholar]
- Meguid M. M., Brennan M. F., Aoki T. T., Muller W. A., Ball M. R., Moore F. D. The role of insulin and glucagon in acute trauma. Surg Forum. 1973;24:97–98. [PubMed] [Google Scholar]
- Meguid M. M., Brennan M. F. Letter: Hyperglucagonaemia after drugs. Lancet. 1974 Feb 23;1(7852):319–319. doi: 10.1016/s0140-6736(74)92639-7. [DOI] [PubMed] [Google Scholar]
- Ross H., Johnston I. D., Welborn T. A., Wright A. D. Effect of abdominal operation on glucose tolerance and serum levels of insulin, growth hormone, and hydrocortisone. Lancet. 1966 Sep 10;2(7463):563–566. doi: 10.1016/s0140-6736(66)93036-4. [DOI] [PubMed] [Google Scholar]
- Wilmore D. W., Lindsey C. A., Moyland J. A., Faloona G. R., Pruitt B. A., Unger R. H. Hyperglucagonaemia after burns. Lancet. 1974 Jan 19;1(7847):73–75. doi: 10.1016/s0140-6736(74)92290-9. [DOI] [PubMed] [Google Scholar]