Abstract
Out of 20 patients with viral hepatitis whose glucose-6-phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more severe than in the group with normal G-6-PD values. Massive intravascular haemolysis occurred in four, three of whom died. The massive haemolysis was attributed to the presence of additional drug-induced oxidative stress to the G-6-PD-deficient red cells.
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- BEUTLER E., DURON O., KELLY B. M. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963 May;61:882–888. [PubMed] [Google Scholar]
- Chan T. K., Chesterman C. N., McFadzean A. J., Todd D. The survival of glucose-6-phosphate dehydrogenase--deficient erythrocytes in patients with typhoid fever on chloramphenicol therapy. J Lab Clin Med. 1971 Feb;77(2):177–184. [PubMed] [Google Scholar]
- Chan T. K., Todd D. Characteristics and distribution of glucose-6-phosphate dehydrogenase-deficient variants in South China. Am J Hum Genet. 1972 Jul;24(4):475–484. [PMC free article] [PubMed] [Google Scholar]
- Chan T. K., Todd D., Wong C. C. Tissue enzyme levels in erythrocyte glucose-6-phosphate dehydrogenase deficiency. J Lab Clin Med. 1965 Dec;66(6):937–942. [PubMed] [Google Scholar]
- Hillman R. S., Finch C. A. The misused reticulocyte. Br J Haematol. 1969 Oct;17(4):313–315. doi: 10.1111/j.1365-2141.1969.tb01377.x. [DOI] [PubMed] [Google Scholar]
- Kattamis C. A., Tjortjatou F. The hemolytic process of viral hepatitis in children with normal or deficient glucose-6-phosphate dehydrogenase activity. J Pediatr. 1970 Sep;77(3):422–430. doi: 10.1016/s0022-3476(70)80010-5. [DOI] [PubMed] [Google Scholar]
- Lee A. K., Tse T. F., Mok C. K. Australia antigen in an open-heart surgical unit in Hong Kong. Aust N Z J Med. 1974 Feb;4(1):8–11. doi: 10.1111/j.1445-5994.1974.tb03138.x. [DOI] [PubMed] [Google Scholar]
- PITCHER C. S., WILLIAMS R. Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism. Clin Sci. 1963 Apr;24:239–252. [PubMed] [Google Scholar]
- Phillips S. M., Silvers N. P. Glucose-6 phosphate dehydrogenase deficiency, infectious hepatitis, acute hemolysis, and renal failure. Ann Intern Med. 1969 Jan;70(1):99–104. doi: 10.7326/0003-4819-70-1-99. [DOI] [PubMed] [Google Scholar]
- Recommended methods for radioisotope red-cell survival studies. A report by the ICSH panel on diagnostic applications of radioisotopes in haematology. Br J Haematol. 1971 Aug;21(2):241–250. doi: 10.1111/j.1365-2141.1971.tb03435.x. [DOI] [PubMed] [Google Scholar]
- Salen G., Goldstein F., Haurani F., Wirts C. W. Acute hemolytic anemia complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency. Ann Intern Med. 1966 Dec;65(6):1210–1220. doi: 10.7326/0003-4819-65-6-1210. [DOI] [PubMed] [Google Scholar]
- THEIL G. B., BRODINE C. E., DOOLAN P. D. Red cell glutathione content and stability in renal insufficiency. J Lab Clin Med. 1961 Nov;58:736–742. [PubMed] [Google Scholar]