Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1975 Feb 22;1(5955):419–422. doi: 10.1136/bmj.1.5955.419

Urinary fibrin-fibrinogen degradation products in nephrotic syndrome.

C L Hall, N Pejhan, J M Terry, J D Blainey
PMCID: PMC1672390  PMID: 803853

Abstract

The urinary concentration of fibrin-fibrinogen degradation products (F.D.P.) was measured in 90 patients with proteinuria above 2 g/1 and correlated with proteinuria, differential protein clearances, serum urea and creatinine, and renal biopsy findings. There was a linear correlation (r equals 0-7; P less than 0-001) between the urinary F.D.P. excretion and the selectivity of the proteinuria such that patients with highly selective proteinuria excreted only small amounts of F.D.P. whereas those with non-selective proteinuria excreted much higher levels. There was a significant correlation between the urinary F.D.P. excretion and the urine:serum (U:S) ratio of IgG excretion but not with the U:S ratio or urinary excretion of albumin or transferrin. Sephadex G200 column chromatography of the concentrated urine in 26 cases showed that patients with highly selective proteinuria excreted predominantly F.D.P. of low molecular weight in the urine whereas those with non-selective proteinuria excreted mainly fibrinogen and products of high molecular weight. Hence the type and quantity of F.D.P. in the urine are determined primarily by the differential filtration of fibrinogen and the various degradation products from the plasma through the glomerular basement membrane, which in turn is determined by the "pore size" of the basement membrane. In clinical nephrology measurement of the urinary F.D.P. level provides a rapid and convenient means of estimating the differential protein clearance.

Full text

PDF
419

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bouma B. N., Hedner U., Nilsson I. M. Typing of fibrinogen degradation products in urine in various clinical disorders. Scand J Clin Lab Invest. 1971 Jun;27(4):331–335. doi: 10.3109/00365517109080226. [DOI] [PubMed] [Google Scholar]
  2. Ekert H., Barratt T. M., Chantler C., Turner M. W. Immunologically reactive equivalents of fibrinogen in sera and urine of children with renal disease. Arch Dis Child. 1972 Feb;47(251):90–96. doi: 10.1136/adc.47.251.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gordon Y. B., Martin M. J., McNeile A. T., Chard T. Specific and sensitive determination of fibrinogen-degradation products by radioimmunoassay. Lancet. 1973 Nov 24;2(7839):1168–1170. doi: 10.1016/s0140-6736(73)92937-1. [DOI] [PubMed] [Google Scholar]
  4. Hedner U., Ekberg M., Nilsson I. M. Urinary fibrin-fibrinogen degradation products (FDP) and glomerulonephritis. Acta Med Scand. 1974 Jan-Feb;195(1-2):81–85. [PubMed] [Google Scholar]
  5. Humair L., Potter E. V., Kwaan H. C. The role of fibrinogen in renal disease. I. Production of experimental lesions in mice. J Lab Clin Med. 1969 Jul;74(1):60–71. [PubMed] [Google Scholar]
  6. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  7. Merskey C., Lalezari P., Johnson A. J. A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proc Soc Exp Biol Med. 1969 Jul;131(3):871–875. doi: 10.3181/00379727-131-33998. [DOI] [PubMed] [Google Scholar]
  8. Naish P., Evans D. J., Peters D. K. Urinary fibrinogen derivative excretion and intraglomerular fibrin deposition in glomerulonephritis. Br Med J. 1974 Mar 23;1(5907):544–546. doi: 10.1136/bmj.1.5907.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rayner H., Parashevas F., Israels L. G., Israels E. D. Fibrinogen breakdown products: identification and assay in serum and urine. J Lab Clin Med. 1969 Oct;74(4):586–596. [PubMed] [Google Scholar]
  10. Shah B. C., Ambrus J. L., Mink I. B., Albert D. J., Sampson D., Murphy G. P. Fibrin degradation products in renal parenchymal disease states and renal transplant patients. Transplantation. 1972 Dec;14(6):705–710. doi: 10.1097/00007890-197212000-00006. [DOI] [PubMed] [Google Scholar]
  11. Wardle E. N. Intravascular coagulation and pre-eclamptic toxaemia. Lancet. 1972 Mar 25;1(7752):694–695. doi: 10.1016/s0140-6736(72)90504-1. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES