Abstract
A cross-over trail of debrisoquine and guanethidine in 32 patients showed that both drugs were equally effective in lowering both systolic and diastolic blood pressure. The degree to which they were tolerated by the patients, however, differed greatly. After three months on each drug 18 patients preferred debrisoquine, nine preferred guanethidine, and five showed no particular preference. At current prices the cost of daily treatment to the patient was cheaper with debrisoquine than with guanethidine.
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Selected References
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- Heffernan A. G., Carty A. T. Clinical observations on the use of debrisoquine sulphate (Declinas) in the treatment of hypertension. Ir J Med Sci. 1970 Jan;3(1):37–43. doi: 10.1007/BF02958732. [DOI] [PubMed] [Google Scholar]
- Heffernan A., Carty A., O'Malley K., Bugler J. A within-patient comparison of debrisoquine and methyldopa in hypertension. Br Med J. 1971 Jan 9;1(5740):75–78. doi: 10.1136/bmj.1.5740.75. [DOI] [PMC free article] [PubMed] [Google Scholar]