Abstract
From September 1962 to May 1972 145 patients with acute or subacute deep vein thrombosis confirmed by phlebography were treated with streptokinase. During the same period 42 patients considered unfit for thrombolytic therapy were treated with herapin and oral anticoagulants. The results, assessed by repeat phlebography, in 93 of the patients treated with streptokinase were compared with those in 42 patients treated with heparin. The age, sex, and severity of occlusion were roughly similar in both groups. Streptokinase treatment was successful in 42 per cent, partially successful in 25 per cent, and unsuccessful in 32 per cent of the 93 patients compared with none, 10 per cent, and 88 percent respectively in the 42 patients treated with heparin. Streptokinase was more effective when the thrombus was in proximal rather than calf veins. Thrombi of more than six days old were readily lysed. Plasma fibrinogen levels were below 0-8 g/1 (80 mg/100 ml) in nearly all patients successfully treated. The incidence of pulmonary embolism was no greater with streptokinase than with heparin treatment. Only prolonged follow-up would show whether thrombolytic treatment would be effective in preventing late complications of deep vein thrombosis such as chronic venous insufficiency.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BACHMANN F., DUCKERT F., KOLLER F. The Stuart-Prower factor assay and its clinical significance. Thromb Diath Haemorrh. 1958 May 1;2(1-2):24–38. [PubMed] [Google Scholar]
- Browse N. L., Thomas M. L., Pim H. P. Streptokinase and deep vein thrombosis. Br Med J. 1968 Sep 21;3(5620):717–720. doi: 10.1136/bmj.3.5620.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLAUSS A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957 Apr;17(4):237–246. doi: 10.1159/000205234. [DOI] [PubMed] [Google Scholar]
- Duckert F., Benz A., Prisender S., da Silva A., Schmitt H. E. Coagulation parameters and success of thrombolytic treatment in deep vein thrombosis. Vasa. 1974;3(2):138–139. [PubMed] [Google Scholar]
- FISCHBACHER W. [A contribution to fibrinolytic therapy with streptokinase and streptolysin]. Thromb Diath Haemorrh. 1961 Dec 15;6:547–572. [PubMed] [Google Scholar]
- KOLLER F., LOELIGER A., DUCKERT F. Experiments on a new clotting factor (factor VII). Acta Haematol. 1951;6(1):1–18. doi: 10.1159/000203899. [DOI] [PubMed] [Google Scholar]
- Kakkar V. V., Flanc C., Howe C. T., O'Shea M., Flute P. T. Treatment of deep vein thrombosis. A trial of heparin, streptokinase, and arvin. Br Med J. 1969 Mar 29;1(5647):806–810. doi: 10.1136/bmj.1.5647.806. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mavor G. E., Dhall D. P., Dawson A. A., Duthie J. S., Walker M. G., Mahaffy R. G., Allardyce M. Streptokinase therapy in deep-vein thrombosis. Br J Surg. 1973 Jun;60(6):468–474. doi: 10.1002/bjs.1800600614. [DOI] [PubMed] [Google Scholar]
- Robertson B. R., Nilsson I. M., Nylander G. Thrombolytic effect of streptokinase as evaluated by phlebography of deep venous thrombi of the leg. Acta Chir Scand. 1970;136(3):173–180. [PubMed] [Google Scholar]
- Seiler K., Müller G., Duckert F. Kontrolle von Heparin und oralen Antikoagulantien mit Mikromethoden: Thrombinzeit, Quick-Bestimmung mit Protaminzusatz. Schweiz Med Wochenschr. 1970 Sep 5;100(36):1522–1528. [PubMed] [Google Scholar]