Abstract
A study of renal biopsy specimens obtained in Senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16 cases). The latter, though lacking the diffuse glomerular deposits of immunoglobulin described in quartan malarial nephropathy (Q.M.N.), showed a curious progressive and segmental glomerulosclerosis, characterized by a "flaking" or fibrillary splitting of the glomerular capillary wall, seen in Q.M.N. Serological evidence of malaria was lacking in a third of the childhood cases.
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- Bhamarapravati N., Boonpucknavig S., Boonpucknavig V., Yaemboonruang C. Glomerular changes in acute plasmodium falciparum infection. An immunopathologic study. Arch Pathol. 1973 Nov;96(5):289–293. [PubMed] [Google Scholar]
- Churg J., Habib R., White R. H. Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children. Lancet. 1970 Jun 20;760(1):1299–1302. doi: 10.1016/s0140-6736(70)91905-7. [DOI] [PubMed] [Google Scholar]
- GIGLIOLI G. Malaria and renal disease, with special reference to British Guiana. II. The effect of malaria eradication on the incidence of renal disease in British Guiana. Ann Trop Med Parasitol. 1962 Jul;56:225–241. doi: 10.1080/00034983.1962.11686115. [DOI] [PubMed] [Google Scholar]
- Habib R., Kleinknecht C., Royer P. Le syndrome nephrotique primitif de l'enfant. Classification et etude anatomo-clinique de 406 observations. Arch Fr Pediatr. 1971;28(3):277–319. [PubMed] [Google Scholar]
- Hendrickse R. G., Adeniyi A., Edington G. M., Glasgow E. F., White R. H., Houba V. Quartan malarial nephrotic syndrome. Collaborative clinicopathological study in Nigerian children. Lancet. 1972 May 27;1(7761):1143–1149. doi: 10.1016/s0140-6736(72)91373-6. [DOI] [PubMed] [Google Scholar]
- Houba V., Allison A. C., Adeniyi A., Houba J. E. Immunoglobulin classes and complement in biopsies of Nigerian children with the nephrotic syndrome. Clin Exp Immunol. 1971 May;8(5):761–774. [PMC free article] [PubMed] [Google Scholar]
- Kibukamusoke J. W., Hutt M. S., Wilks N. E. The nephrotic syndrome in Uganda and its association with quartan malaria. Q J Med. 1967 Jul;36(143):393–408. [PubMed] [Google Scholar]
- Morel-Maroger L. J., Saimot A. G., Adam C. M., Niang I., Sloper J. C., Payet M. I. Etude anatomo-clinique, immuno-pathologique et ultrastructurale de 16 néphropathies glomérulaires en zone inter-tropicale (résultats préliminaires. C R Acad Sci Hebd Seances Acad Sci D. 1973 Apr 25;276(17):2477–2479. [PubMed] [Google Scholar]
- Morel-Maroger L., Leathem A., Richet G. Glomerular abnormalities in nonsystemic diseases. Relationship between findings by light microscopy and immunofluorescence in 433 renal biopsy specimens. Am J Med. 1972 Aug;53(2):170–184. doi: 10.1016/0002-9343(72)90127-1. [DOI] [PubMed] [Google Scholar]
- Rothfield N., Ross H. A., Minta J. O., Lepow I. H. Glomerular and dermal depostion of properdin in systemic lupus erythematosus. N Engl J Med. 1972 Oct 5;287(14):681–685. doi: 10.1056/NEJM197210052871402. [DOI] [PubMed] [Google Scholar]
- Voller A., Davies D. R., Hutt M. S. Quartan malarial infections in Aotus trivirgatus with special reference to renal pathology. Br J Exp Pathol. 1973 Oct;54(5):457–468. [PMC free article] [PubMed] [Google Scholar]
- White R. H. Quartan malarial nephrotic syndrome. Nephron. 1973;11(2):147–162. doi: 10.1159/000180227. [DOI] [PubMed] [Google Scholar]
- Wing A. J., Kibukamusoke J. W., Hutt M. S. Poststreptococcal glomerulonephritis and the nephrotic syndrome in Uganda. Trans R Soc Trop Med Hyg. 1971;65(5):543–548. doi: 10.1016/0035-9203(71)90035-6. [DOI] [PubMed] [Google Scholar]