Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1975 Mar 8;1(5957):550–551. doi: 10.1136/bmj.1.5957.550

Mitigation of amphotericin B nephrotoxicity by mannitol.

J J Olivero, J Lozano-Mendez, E M Ghafary, G Eknoyan, W N Suki
PMCID: PMC1672628  PMID: 1095113

Abstract

Renal transplant recipients are susceptible to a number of fungal infections amenable to therapy with amphotericin B, but azotaemia is an almost invariable sequel to the use of this agent. As intravenous mannitol has been shown to minimize nephrotoxicity induced by amphotericin B in dogs we treated four kidney transplant recipients who had systemic fungal infections with mannitol and amphotericin B. None showed significant reduction in renal function though a mild metabolic acidosis did develop.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELL N. H., ANDRIOLE V. T., SABESIN S. M., UTZ J. P. On the nephrotoxicity of amphotericin B in man. Am J Med. 1962 Jul;33:64–69. doi: 10.1016/0002-9343(62)90277-2. [DOI] [PubMed] [Google Scholar]
  2. Butler W. T. Pharmacology, toxicity, and therapeutic usefulness of amphotericin B. JAMA. 1966 Jan 31;195(5):371–375. [PubMed] [Google Scholar]
  3. Feldman H. A., Hamilton J. D., Gutman R. A. Amphotericin B therapy in an anephric patient. Antimicrob Agents Chemother. 1973 Sep;4(3):302–305. doi: 10.1128/aac.4.3.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Flores J., DiBona D. R., Beck C. H., Leaf A. The role of cell swelling in ischemic renal damage and the protective effect of hypertonic solute. J Clin Invest. 1972 Jan;51(1):118–126. doi: 10.1172/JCI106781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gouge T. H., Andriole V. T. An experimental model of amphotericin B nephrotoxicity with renal tubular acidosis. J Lab Clin Med. 1971 Nov;78(5):713–724. [PubMed] [Google Scholar]
  6. Hellebusch A. A., Salama F., Eadie E. The use of mannitol to reduce the nephrotoxicity of amphotericin B. Surg Gynecol Obstet. 1972 Feb;134(2):241–243. [PubMed] [Google Scholar]
  7. McCurdy D. K., Frederic M., Elkinton J. R. Renal tubular acidosis due to amphotericin B. N Engl J Med. 1968 Jan 18;278(3):124–130. doi: 10.1056/NEJM196801182780302. [DOI] [PubMed] [Google Scholar]
  8. Miller R. P., Bates J. H. Amphotericin B toxicity. A follow-up report of 53 patients. Ann Intern Med. 1969 Dec;71(6):1089–1095. doi: 10.7326/0003-4819-71-6-1089. [DOI] [PubMed] [Google Scholar]
  9. Patterson R. M., Ackerman G. L. Renal tubular acidosis due to amphotericin B nephrotoxicity. Arch Intern Med. 1971 Feb;127(2):241–244. [PubMed] [Google Scholar]
  10. Teschan P. E., Lawson N. L. Studies in acute renal failure. Prevention by osmotic diuresis, and observations on the effect of plasma and extracellular volume expansion. Nephron. 1966;3(1):1–16. doi: 10.1159/000179422. [DOI] [PubMed] [Google Scholar]
  11. WERTLAKE P. T., BUTLER W. T., HILL G. J., 2nd, UTZ J. P. NEPHROTOXIC TUBULAR DAMAGE AND CALCIUM DEPOSITION FOLLOWING AMPHOTERICIN B THERAPY. Am J Pathol. 1963 Sep;43:449–457. [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES