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. 1975 Apr 5;2(5961):15–17. doi: 10.1136/bmj.2.5961.15

Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine.

A P Hall, E B Doberstyn, V Mettaprakong, P Sonkom
PMCID: PMC1672967  PMID: 1093610

Abstract

Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 X 10-9/1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ansdell V. E., Boosey C. M., Geddes A. M., Morgan H. V. Malaria in Birmingham 1968-73. Br Med J. 1974 Apr 27;2(5912):206–208. doi: 10.1136/bmj.2.5912.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bartelloni P. J., Sheehy T. W., Tigertt W. D. Combined therapy for chloroquine-resistant, Plasmodium falciparum infection. Concurrent use of long-acting sulphormethoxine and pyrimethamine. JAMA. 1967 Jan 16;199(3):173–177. [PubMed] [Google Scholar]
  3. Brooks M. H., Malloy J. P., Bartelloni P. J., Sheehy T. W., Barry K. G. Quinine, pyrimethamine, and sulphorthodimethoxine: clinical response, plasma levels, and urinary excretion during the initial attack of naturally acquired falciparum malaria. Clin Pharmacol Ther. 1969 Jan-Feb;10(1):85–91. doi: 10.1002/cpt196910185. [DOI] [PubMed] [Google Scholar]
  4. Chin W., Contacos P. G., Coatney G. R., King H. K. The evaluation of sulfonamides, alone or in combination with pyrimethamine, in the treatment of multi-resistant falciparum malaria. Am J Trop Med Hyg. 1966 Nov;15(6):823–829. doi: 10.4269/ajtmh.1966.15.823. [DOI] [PubMed] [Google Scholar]
  5. Glazko A. J., Dill W. A., Montalbo R. G., Holmes E. L. A new analytical procedure for dapsone. Application to blood-level and urinary-excretion studies in normal men. Am J Trop Med Hyg. 1968 May;17(3):465–473. [PubMed] [Google Scholar]
  6. Hall A. P., Czerwinski A. W., Madonia E. C., Evensen K. L. Human plasma and urine quinine levels following tablets, capsules, and intravenous infusion. Clin Pharmacol Ther. 1973 Jul-Aug;14(4):580–585. doi: 10.1002/cpt1973144part1580. [DOI] [PubMed] [Google Scholar]
  7. Hall A. P. Quinine fever in falciparum malaria. Southeast Asian J Trop Med Public Health. 1974 Sep;5(3):413–416. [PubMed] [Google Scholar]
  8. LAING A. B. ANTIMALARIAL EFFECT OF SULPHORTHODIMETHOXINE (FANASIL). Br Med J. 1964 Dec 5;2(5422):1439–1440. doi: 10.1136/bmj.2.5422.1439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Neva F. A., Sheagren J. N., Shulman N. R., Canfield C. J. Malaria: host-defense mechanisms and complications. Ann Intern Med. 1970 Aug;73(2):295–306. doi: 10.7326/0003-4819-73-2-295. [DOI] [PubMed] [Google Scholar]
  10. Richards W. H. The combined action of pyrimidines and sulfonamides or sulfones in the chemotherapy of malaria and other protozoal infections. Adv Pharmacol Chemother. 1970;8:121–147. doi: 10.1016/s1054-3589(08)60595-5. [DOI] [PubMed] [Google Scholar]
  11. SMITH C. C., IHRIG J. Persistent excretion of pyrimethamine following oral administration. Am J Trop Med Hyg. 1959 Jan;8(1):60–62. doi: 10.4269/ajtmh.1959.8.60. [DOI] [PubMed] [Google Scholar]
  12. Schwartz D. E., Rieder J. Pharmacokinetics of sulfamethoxazole plus trimethoprim in man and their distribution in the rat. Chemotherapy. 1970;15(6):337–355. doi: 10.1159/000220701. [DOI] [PubMed] [Google Scholar]
  13. Seneca H. Long-acting sulfonamides in urinary tract infections. JAMA. 1966 Nov 28;198(9):975–980. [PubMed] [Google Scholar]

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