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. 1975 Apr 5;2(5961):7–9. doi: 10.1136/bmj.2.5961.7

Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis.

M Aylward, R J Parker, F Holly, J Maddock, D B Davies
PMCID: PMC1672980  PMID: 236805

Abstract

Indomethacin and alclofenac were compared for 13 months under double-blind conditions in 109 patients with active, classical, or definite rheumatoid arthritis at a relatively early stage of the disease. Both indomethacin and alclofenac were clearly effective: most patients either improved or remained as well controlled as on entry. Alclofenac proved the more effective drug, however, producing a significantly greater reduction in morning stiffness, articular index, and erythrocyte sedimentation rate, and only in the alclofenac-treated group did functional capacity improve and latex-agglutination titres diminish. Comprehensive laborabory tests showed no significant deviation from normal which could have been attributed to either drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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