Abstract
Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria. Combination therapy with full-dose quinine and clindamycin for three days cured all four patients so treated who were followed up, and with half dosage three out of five patients were cured. Both combinations, however, caused upper gastrointestinal toxicity and appeared to potentiate both toxicity and possibly antimalarial efficacy. Colitis due to clindamycin was not observed. Sequential therapy was not toxic and could be useful in patients who have relapsed after more conventional treatment.
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Selected References
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- Brooks M. H., Malloy J. P., Bartelloni P. J., Sheehy T. W., Barry K. G. Quinine, pyrimethamine, and sulphorthodimethoxine: clinical response, plasma levels, and urinary excretion during the initial attack of naturally acquired falciparum malaria. Clin Pharmacol Ther. 1969 Jan-Feb;10(1):85–91. doi: 10.1002/cpt196910185. [DOI] [PubMed] [Google Scholar]
- Cohen L. E., McNeill C. J., Wells R. F. Clindamycin-associated colitis. JAMA. 1973 Mar 19;223(12):1379–1380. [PubMed] [Google Scholar]
- Lewis C. Antiplasmodial activity of 7-halogenated lincomycins. J Parasitol. 1968 Feb;54(1):169–170. [PubMed] [Google Scholar]
- Pittman F. E., Pittman J. C., Humphrey C. D. Letter: Lincomycin and pseudomembranous colitis. Lancet. 1974 Mar 16;1(7855):451–452. doi: 10.1016/s0140-6736(74)92402-7. [DOI] [PubMed] [Google Scholar]
- Powers K. G. Activity of chlorinated lincomycin analogues against Plasmodium cynomolgi in rhesus monkeys. Am J Trop Med Hyg. 1969 Jul;18(4):485–490. doi: 10.4269/ajtmh.1969.18.485. [DOI] [PubMed] [Google Scholar]
- Powers K. G., Jacobs R. L. Activity of two chlorinated lincomycin analogues against chloroquine-resistant falciparum malaria in owl monkeys. Antimicrob Agents Chemother. 1972 Jan;1(1):49–53. doi: 10.1128/aac.1.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schmidt L. H., Harrison J., Ellison R., Worcester P. The activities of chlorinated lincomycin derivatives against infections with Plasmodium cynomolgi in Macaca mulatta. Am J Trop Med Hyg. 1970 Jan;19(1):1–11. doi: 10.4269/ajtmh.1970.19.1. [DOI] [PubMed] [Google Scholar]
- Tedesco F. J., Stanley R. J., Alpers D. H. Diagnostic features of clindamycin-associated pseudomembranous colitis. N Engl J Med. 1974 Apr 11;290(15):841–843. doi: 10.1056/NEJM197404112901508. [DOI] [PubMed] [Google Scholar]