Abstract
The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics. AH 5158, like propranolol, is a non-cardioselective beta-adrenoceptor-blocking drug, but unlike propranolol it also has an alpha-adrenoceptor-blocking action. Both drugs produced equivalent cardiac(beta1) blockade, but propranolol produced bronchoconstriction, whereas AH 5158 did not. Hence the alpha-blocking action of AH 5158 seems to prevent the bronchoconstrictor effects of propranolol in these patients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bianco S., Griffin J. P., Kamburoff P. L., Prime F. J. The effect of thymoxamine on histamine induced bronchospasm in man. Br J Dis Chest. 1972 Jan;66(1):27–32. [PubMed] [Google Scholar]
- Boakes A. J., Knight E. J., Prichard B. N. Preliminary studies of the pharmacological effects of 5-[1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)-ethyl] salicylamide (AH 5158) in man. Clin Sci. 1971 Apr;40(4):18P–19P. doi: 10.1042/cs040018pa. [DOI] [PubMed] [Google Scholar]
- Farmer J. B., Kennedy I., Levy G. P., Marshall R. J. Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors. Br J Pharmacol. 1972 Aug;45(4):660–675. doi: 10.1111/j.1476-5381.1972.tb08125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaddie J., Legge J. S., Petrie G., Palmer K. N. The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma. Br J Dis Chest. 1972 Apr;66(2):141–146. [PubMed] [Google Scholar]
- Kerr J. W., Govindaraj M., Patel K. R. Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma. Br Med J. 1970 Apr 18;2(5702):139–141. doi: 10.1136/bmj.2.5702.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leary W. P., Coleman A. J., Asmal A. C. Respiratory effects of acebutolol hydrochloride. S Afr Med J. 1973 Jul 21;47(28):1245–1248. [PubMed] [Google Scholar]
- Macdonald A. G., McNeill R. S. A comparison of the effect on airway resistance of a new beta blocking drug, ICI.50,172 and propranolol. Br J Anaesth. 1968 Jul;40(7):508–510. doi: 10.1093/bja/40.7.508. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Diament M. L. Dynamic and static lung volumes and blood-gas tensions in bronchial asthma. Lancet. 1969 Mar 22;1(7595):591–593. doi: 10.1016/s0140-6736(69)91531-1. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Hamilton W. F., Lge J. S., Diament M. L. Effect of a selectivebeta-adrenergic blocker in preventing falls in arterial oxygen tension following isoprenaline in asthmatic subjects. Lancet. 1969 Nov 22;2(7630):1092–1094. doi: 10.1016/s0140-6736(69)90701-6. [DOI] [PubMed] [Google Scholar]