Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1975 May 17;2(5967):367–370. doi: 10.1136/bmj.2.5967.367

Controlled study of atenolol in treatment of hypertension.

L Hansson, H Aberg, B E Karlberg, A Westerlund
PMCID: PMC1673197  PMID: 236810

Abstract

The antihypertensive effect of atenolol, a new beta-1-receptor blocking agent, was studied in a double-blind trial in which 45 patients with essential hypertension were randomly assigned to placebo or atenolol treatment. Atenolol caused a statistically significant and clinically relevant reduction of blood pressure. The optimum daily dose for moderately severe hypertension was considered to be 200 mg. Several irrelevant side effects were collected by the use of a check list, but there was no difference in the number of complaints during placebo and active treatment. Atenolol has a useful antihypertensive effect and, at least theoretically, has advantages over other beta-adrenergic blocking agents.

Full text

PDF
367

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aberg H. Plasma renin activity after the use of a new beta-adrenergic blocking agent (I.C.I. 66,032). Int J Clin Pharmacol. 1974 Mar;9(2):98–100. [PubMed] [Google Scholar]
  2. Amery A., Billiet L., Fagard R. Letter: Beta receptors and renin release. N Engl J Med. 1974 Jan 31;290(5):284–284. doi: 10.1056/NEJM197401312900516. [DOI] [PubMed] [Google Scholar]
  3. Berglund G., Hansson L. A within-patient comparison of alprenolol and propranolol in hypertension. Acta Med Scand. 1973 Jun;193(6):547–550. doi: 10.1111/j.0954-6820.1973.tb10624.x. [DOI] [PubMed] [Google Scholar]
  4. Bühler F. R., Laragh J. H., Baer L., Vaughan E. D., Jr, Brunner H. R. Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med. 1972 Dec 14;287(24):1209–1214. doi: 10.1056/NEJM197212142872401. [DOI] [PubMed] [Google Scholar]
  5. Hansson L., Aberg H., Jameson S., Karlberg B., Malmcrona R. Initial clinical experience with I.C.I. 66.082, a new beta-adrenergic blocking agent, in hypertension. Acta Med Scand. 1973 Dec;194(6):549–550. doi: 10.1111/j.0954-6820.1973.tb19489.x. [DOI] [PubMed] [Google Scholar]
  6. Hansson L., Malmcrona R., Olander R., Rosenhall L., Westerlund A., Aberg H., Hood B. Propranolol in hypertension. Report on 158 patients treated up to one year. Klin Wochenschr. 1972 Apr 1;50(7):364–369. doi: 10.1007/BF01486832. [DOI] [PubMed] [Google Scholar]
  7. Hansson L., Zweifler A. J., Julius S., Hunyor S. N. Hemodynamic effects of acute and prolonged beta-adrenergic blockade in essential hypertension. Acta Med Scand. 1974 Jul-Aug;196(1-2):27–34. doi: 10.1111/j.0954-6820.1974.tb00962.x. [DOI] [PubMed] [Google Scholar]
  8. Hansson L., Zweifler A. J. The effct of propranolol on plasma renin activity and blood pressure in mild essential hypertension. Acta Med Scand. 1974 May;195(5):397–401. doi: 10.1111/j.0954-6820.1974.tb08159.x. [DOI] [PubMed] [Google Scholar]
  9. Huskisson E. C., Wojtulewski J. A. Measurement of side effects of drugs. Br Med J. 1974 Jun 29;2(5921):698–699. doi: 10.1136/bmj.2.5921.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kincaid-Smith P. Management of severe hypertension. Am J Cardiol. 1973 Sep 20;32(4):575–581. doi: 10.1016/s0002-9149(73)80049-9. [DOI] [PubMed] [Google Scholar]
  11. PRICHARD B. N., GILLAM P. M. USE OF PROPRANOLOL (INDERAL) IN TREATMENT OF HYPERTENSION. Br Med J. 1964 Sep 19;2(5411):725–727. doi: 10.1136/bmj.2.5411.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Prichard B. N., Gillam P. M. Propranolol in hypertension. Am J Cardiol. 1966 Sep;18(3):387–393. doi: 10.1016/0002-9149(66)90059-2. [DOI] [PubMed] [Google Scholar]
  13. Tarazi R. C., Dustan H. P. Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations. Am J Cardiol. 1972 May;29(5):633–640. doi: 10.1016/0002-9149(72)90164-6. [DOI] [PubMed] [Google Scholar]
  14. Vedin J. A., Wilhelmsson C. E., Werkö L. Comparative study of alprenolol and methyldopa in previously untreated essential hypertension. Br Heart J. 1973 Dec;35(12):1285–1292. doi: 10.1136/hrt.35.12.1285. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES