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. 1975 May 31;2(5969):467–470. doi: 10.1136/bmj.2.5969.467

Immune status of children with and without severe infection during remission of malignant disease.

J Graham-Pole, M L Willoughby, S Aitken, A Ferguson
PMCID: PMC1673450  PMID: 1148660

Abstract

The immune status of children with malignant disease in remission was assessed usingvarious immune function tests. Children with infections had significantlymore neutropenia, hypogammaglobulinaemia, and impaired cell-mediated immune responses than those without. These two groups combined had much more absolute lymphopenia and impairment of both cell-mediated immunity and antibody-producing capacity thancontrol children with non-malignant conditions. Regular immunological evaluation isrecommended for children with malignant disease when new intensive treatment schedules are under trial and for individual patients particularly prone to develop infections during treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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