Abstract
The ratio of derived phenobarbitone to unmetabolized primidone in the serum was significantly higher in 50 epileptic patients on a combination of primidone and phenytoin than in 12 patients on primidone alone, though the dose and serum levels of primidone were similar in the two groups. Out of 253 patients attending a seizure clinic 47% were taking a combination of these two anticonvulsants. The effect of phenytoin on the metabolism of primidone may have clinical implications in view of the frequency of their combined use.
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Selected References
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- Fincham R. W., Schottelius D. D., Sahs A. L. The influence of diphenylhydantoin on primidone metabolism. Arch Neurol. 1974 Mar;30(3):259–262. doi: 10.1001/archneur.1974.00490330067012. [DOI] [PubMed] [Google Scholar]
- Morselli P. L., Rizzo M., Garattini S. Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients. Ann N Y Acad Sci. 1971 Jul 6;179:88–107. doi: 10.1111/j.1749-6632.1971.tb46892.x. [DOI] [PubMed] [Google Scholar]
- Rizzo M., Morselli P. L., Garattini S. Further observations on the interactions between phenobarbital and diphenylhydantoin during chronic treatment in the rat. Biochem Pharmacol. 1972 Feb 15;21(4):449–454. doi: 10.1016/0006-2952(72)90317-6. [DOI] [PubMed] [Google Scholar]