Abstract
Infant leukaemias differ from childhood leukaemias in ways which suggest that when haemopoietic neoplasms combine fetal origins with rapid growth rates they prevent normal development of the reticuloendothelial system and thus cause the sudden death of apparently healthy babies (stillbirths or cot deaths). Cot deaths are commoner in boys and have a peak incidence during the first half of infancy-that is, during the period most affected by the switch from passive to active immunity. Babies born from July to December, who are intensively exposed to winter conditions form 1 to 5 months of age, are also at special risk. During this period more girls and more children born form January to June die of leukaemia; and within three months of birth an exceptionally high ratio of myeloid to lymphatic leukaemias has been replaced by a low ratio, which persists throughout childhood.
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Selected References
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- August J. T. Mechanism of synthesis of bacteriophage RNA. Nature. 1969 Apr 12;222(5189):121–123. doi: 10.1038/222121a0. [DOI] [PubMed] [Google Scholar]
- Fedrick J. Sudden unexpected death in infants in the Oxford record linkage area. An analysis with respect to time and place. Br J Prev Soc Med. 1973 Nov;27(4):217–224. doi: 10.1136/jech.27.4.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Froggatt P., Lynas M. A., MacKenzie G. Epidemiology of sudden unexpected death in infants ('cot death') in Northern Ireland. Br J Prev Soc Med. 1971 Aug;25(3):119–134. doi: 10.1136/jech.25.3.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart A. M. Cancer as a cause of abortions and stillbirths: the effect of these early deaths on the recognition of radiogenic leukaemias. Br J Cancer. 1973 Jun;27(6):465–472. doi: 10.1038/bjc.1973.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart A. M., Kneale G. W. Age-distribution of cancers caused by obstetric x-rays and their relevance to cancer latent periods. Lancet. 1970 Jul 4;2(7662):4–8. doi: 10.1016/s0140-6736(70)92472-4. [DOI] [PubMed] [Google Scholar]