Abstract
In a double-blind trial 45 children aged 6 months to 14 years with Escherichia coli infections of the urinary tract were given co-trimoxazole for two weeks and then allotted at random to one of two treatment groups for the remainder of six months; one continued with the active drug and the other with dummy tablets of identical appearance. Of the 24 children who took co-trimoxazole for two weeks and the 21 who took it for six months, 11 and 10, respectively, remained without further infections for at least a year. Over 90% of the reinfections occurred within five months of stopping the antibiotics, and the longer treatment did not cause any delay in their appearance. Thus probably a six-month course of treatment is no more likely to achieve a cure than a two-week course; nevertheless, no infection occurred during treatment, and there may be an advantage in continuing with antibiotics in small dosage.
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Selected References
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- Bergström T., Lincoln K., Redin B., Winberg J. Studies of urinary tract infections in infancy and childhood. X. Short or long-term treatment in girls with first or second-time urinary tract infections uncomplicated by obstructive urological abnormalities. Acta Paediatr Scand. 1968 May;57(3):186–194. doi: 10.1111/j.1651-2227.1968.tb04677.x. [DOI] [PubMed] [Google Scholar]
- HOLLAND N. H., WEST C. D. Prevention of recurrent urinary tract infections in girls. Am J Dis Child. 1963 Jun;105:560–567. doi: 10.1001/archpedi.1963.02080040562006. [DOI] [PubMed] [Google Scholar]
- Kincaid-Smith P., Fairley K. F. Controlled trial comparing effect of two and six weeks' treatment in recurrent urinary tract infection. Br Med J. 1969 Apr 19;2(5650):145–146. doi: 10.1136/bmj.2.5650.145. [DOI] [PMC free article] [PubMed] [Google Scholar]