Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1975 Jul 12;3(5975):73–74. doi: 10.1136/bmj.3.5975.73

Prophylactic fluoride treatment and aged bones.

J Inkovaara, R Heikinheimo, K Jarvinen, U Kasurinen, H Hanhijarvi, E Iisalo
PMCID: PMC1673673  PMID: 1095134

Abstract

In a double-blind trial with monofluorophosphate (25 mg fluoride per day) given to 460 aged persons (237 treated, 233 control) for eight months no difference was observed in height, admission to hospital, or mortality. Fractures and exacerbation of arthrosis were more frequent in the fluoride group. Vertebral x-ray films showed no difference. The free ionized fluoride levels in the plasma of the fluoride-treated group were still twice as high two months after treatment ended. Fluoride treatment in the prophylaxis of osteoporosis is not recommended unless there is simultaneous measurement of plasma ionized fluoride levels.

Full text

PDF
73

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernstein D. S., Cohen P. Use of sodium fluoride in the treatment of osteoporosis. J Clin Endocrinol Metab. 1967 Feb;27(2):197–210. doi: 10.1210/jcem-27-2-197. [DOI] [PubMed] [Google Scholar]
  2. Bernstein D. S., Sadowsky N., Hegsted D. M., Guri C. D., Stare F. J. Prevalence of osteoporosis in high- and low-fluoride areas in North Dakota. JAMA. 1966 Oct 31;198(5):499–504. [PubMed] [Google Scholar]
  3. Cass R. M., Croft J. D., Jr, Perkins P., Nye W., Waterhouse C., Terry R. New bone formation in osteoporosis following treatment with sodium fluoride. Arch Intern Med. 1966 Aug;118(2):111–116. [PubMed] [Google Scholar]
  4. Fry B. W., Taves D. R. Serum fluoride analysis with the fluoride electrode. J Lab Clin Med. 1970 Jun;75(6):1020–1025. [PubMed] [Google Scholar]
  5. Jowsey J., Riggs B. L., Kelly P. J., Hoffmann D. L. Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis. Am J Med. 1972 Jul;53(1):43–49. doi: 10.1016/0002-9343(72)90114-3. [DOI] [PubMed] [Google Scholar]
  6. Jowsey J., Schenk R. K., Reutter F. W. Some results of the effect of fluoride on bone tissue in osteoporosis. J Clin Endocrinol Metab. 1968 Jun;28(6):869–874. doi: 10.1210/jcem-28-6-869. [DOI] [PubMed] [Google Scholar]
  7. Korns R. F. Relationship of water fluoridation to bone density in two N.Y. towns. Public Health Rep. 1969 Sep;84(9):815–825. [PMC free article] [PubMed] [Google Scholar]
  8. Kuhlencordt F., Kruse H. P., Lozano-Tonkin C., Eckermeier L. Therapie der Osteoporose mit Natriumfluorid. Morphologische Knochenbefunde bei acht Fallen. Dtsch Med Wochenschr. 1969 Aug 29;94(35):1730–1734. doi: 10.1055/s-0028-1110334. [DOI] [PubMed] [Google Scholar]
  9. Rich C., Ivanovich P. Response to sodium fluoride in severe primary osteoporosis. Ann Intern Med. 1965 Dec;63(6):1069–1074. doi: 10.7326/0003-4819-63-6-1069. [DOI] [PubMed] [Google Scholar]
  10. Taves D. R. Evidence that there are two forms of fluoride in human serum. Nature. 1968 Mar 16;217(5133):1050–1051. doi: 10.1038/2171050b0. [DOI] [PubMed] [Google Scholar]
  11. Taves D. R. New approach to the treatment of bone disease with fluoride. Fed Proc. 1970 May-Jun;29(3):1185–1187. [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES