Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1975 Aug 9;3(5979):348–349. doi: 10.1136/bmj.3.5979.348

Detection of cannabis products in urine by radioimmunoassay.

V Marks, D Teale, D Fry
PMCID: PMC1673774  PMID: 1156750

Abstract

A radioimmunoassay specific for the closed, three-ringed cannabinoid nucleus was used to detect and measure caname from hospital inpatients not suspected of taking drugs. None of these contained tetrahydro-cannabinol cross-reacting cannabinoids (THC-CRC). The other 393 specimens were from patients known or suspected to be taking various drugs. Of these 51 out of 162 from one hospital treatment clinic and 19 out of 50 from another were positive for THC-CRC. Out of 107 urine specimens from an independent drug treatment clinic 71 were positive for THC-CRC, as were 13 out of 74 specimens from patients in whom drug misuse was suspected or thought possible.

Full text

PDF
348

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agurell S., Gustafsson B., Holmstedt B., Leander K., Lindgren J. E., Nilsson I., Sandberg F., Asberg M. Quantitation of 1-tetrahydrocannabinol in plasma from cannabis smokers. J Pharm Pharmacol. 1973 Jul;25(7):554–558. doi: 10.1111/j.2042-7158.1973.tb09156.x. [DOI] [PubMed] [Google Scholar]
  2. Allen J. T., Fry D., Marks V. Urine spot-test for methaqualone. Lancet. 1970 May 2;1(7653):951–952. doi: 10.1016/s0140-6736(70)91077-9. [DOI] [PubMed] [Google Scholar]
  3. Dole V. P., Kim W. K., Eglitis I. Detection of narcotic drugs, tranquilizers, amphetamines, and barbiturates in urine. JAMA. 1966 Oct 24;198(4):349–352. [PubMed] [Google Scholar]
  4. Fairbairn J. W., Hindmarch I., Simic S., Tylden E. Cannabinoid content of some English reefers. Nature. 1974 May 17;249(454):276–278. doi: 10.1038/249276a0. [DOI] [PubMed] [Google Scholar]
  5. Gross S. J., Soares J. R., Wong S. L., Schuster R. E. Marijuana metabolites measured by a radioimmune technique. Nature. 1974 Dec 13;252(5484):581–582. doi: 10.1038/252581a0. [DOI] [PubMed] [Google Scholar]
  6. Hollister L. E., Kanter S. L., Board R. D., Green D. E. Marihuana metabolites in urine of man. III. Unchanged delta-9-tetrahydrocannabinol. Res Commun Chem Pathol Pharmacol. 1974 Aug;8(4):579–584. [PubMed] [Google Scholar]
  7. Marks V., Fry D., Chapple P. A., Gray G. Application of urine analysis to diagnosis and treatment of heroin addiction. Br Med J. 1969 Apr 19;2(5650):153–155. doi: 10.1136/bmj.2.5650.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marks V. Laboratory investigation of drug addiction. Br J Addict Alcohol Other Drugs. 1966 Aug;61(3):291–294. doi: 10.1111/j.1360-0443.1966.tb04942.x. [DOI] [PubMed] [Google Scholar]
  9. Mitcheson M., Hawks D., Malone S., Davidson J., Hitchens L. Sedative abuse by heroin addicts. Lancet. 1970 Mar 21;1(7647):606–607. doi: 10.1016/s0140-6736(70)91640-5. [DOI] [PubMed] [Google Scholar]
  10. Rosenfeld J. J., Bowins B., Roberts J., Perkins J., Macpherson A. S. Mass fragmentographic assay for delta 9-tetrahydrocannabinol in plasma. Anal Chem. 1974 Dec;46(14):2232–2234. doi: 10.1021/ac60350a047. [DOI] [PubMed] [Google Scholar]
  11. Stimson G. V., Ogborne A. C. Survey of addicts prescribed heroin at London clinics. Lancet. 1970 May 30;1(7657):1163–1166. doi: 10.1016/s0140-6736(70)91230-4. [DOI] [PubMed] [Google Scholar]
  12. Teale J. D., Forman E. J., King L. J., Marks V. Production of antibodies to tetrahydrocannabinol as the basis for its radioimmunoassay. Nature. 1974 May 10;249(453):154–155. doi: 10.1038/249154a0. [DOI] [PubMed] [Google Scholar]
  13. Teale J. D., Forman E. J., King L. J., Marks V. Radioimmunoassay of cannabinoids in blood and urine. Lancet. 1974 Sep 7;2(7880):553–555. doi: 10.1016/s0140-6736(74)91878-9. [DOI] [PubMed] [Google Scholar]
  14. Teale J. D., Forman E. J., King L. J., Piall E. M., Marks V. The development of a radioimmunoassay for cannabinoids in blood and urine. J Pharm Pharmacol. 1975 Jul;27(7):465–472. doi: 10.1111/j.2042-7158.1975.tb09486.x. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES