Abstract
Pigs susceptible to the fulminant hyperthermia-stress syndrome spontaneously developed the hyperthermia syndrome. Basal metabolic rates 10-fold higher than normal were observed in these animals. The metabolic rate exceeded a 17-fold increase over normal with a total heat production of over 28.25 J (6;76 kcal) h-1 kg-1. Heat loss by radiation ceased early in the syndrome, possibly owing to intense peripheral vasoconstriction--a finding which suggests that in man vasodilators might have an important therapeutic role.
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Selected References
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- Britt B. A., Kalow W. Malignant hyperthermia: a statistical review. Can Anaesth Soc J. 1970 Jul;17(4):293–315. doi: 10.1007/BF03004694. [DOI] [PubMed] [Google Scholar]
- Clark M. G., Williams C. H., Pfeifer W. F., Bloxham D. P., Holland P. C., Taylor C. A., Lardy H. A. Letter: Accelerated substrate cycling of fructose-6-phosphate in the muscle of malignant hyperthermic pigs. Nature. 1973 Sep 14;245(5420):99–101. doi: 10.1038/245099a0. [DOI] [PubMed] [Google Scholar]