Abstract
Nine pregnancies are described in patients with pituitary tumours. All patients had definite radiological evidence of a pituitary tumour and no evidence of acromegaly or Cushing's disease. In seven patients serum prolactin levels were estimated before pregnancy and found to be raised.
Seven patients had been treated with pituitary implantation of yttrium-90. The remaining two developed complications of the tumour during pregnancy. One developed a bitemporal visual field defect in the second trimester which was successfully treated by emergency yttrium-90 implantation. The other developed diabetes insipidus in the third trimester which resolved spontaneously after delivery.
Six patients were treated with drugs to achieve pregnancy. Four took bromocriptine to suppress raised prolactin levels, one was treated with human menopausal gonadotrophin, and one was treated with clomiphene.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burke C. W., Joplin G. F., Fraser R. Pituitary tumour treated by pituitary implantation of yttrium 90 during or before pregnancy (two cases). Proc R Soc Med. 1972 May;65(5):486–488. [PMC free article] [PubMed] [Google Scholar]
- Child D. F., Nader S., Mashiter K., Kjeld M., Banks L., Fraser T. R. Prolactin studies in "functionless" pituitary tumours. Br Med J. 1975 Mar 15;1(5958):604–606. doi: 10.1136/bmj.1.5958.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FORBES A. P., HENNEMAN P. H., GRISWOLD G. C., ALBRIGHT F. Syndrome characterized by galactorrhea, amenorrhea and low urinary FSH: comparison with acromegaly and normal lactation. J Clin Endocrinol Metab. 1954 Mar;14(3):265–271. doi: 10.1210/jcem-14-3-265. [DOI] [PubMed] [Google Scholar]
- Jacobs H., Franks S. Letter: Prolactin studies, pituitary tumour, and reproductive function. Br Med J. 1975 Apr 19;2(5963):141–142. doi: 10.1136/bmj.2.5963.141-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Joplin G. F., Jackson R. A., Arnot R. N., Burke C. W., Doyle F. H., Harsoulis P., Lewis P. D., Macerlean D. P., Marshall J. C., Van Noorden S. The effect of yttrium-90 implantation on endocrine function and visual fields in patients with "functionless" pituitary tumors, with biopsy and radiological findings. Clin Endocrinol (Oxf) 1975 Mar;4(2):139–163. doi: 10.1111/j.1365-2265.1975.tb01522.x. [DOI] [PubMed] [Google Scholar]
- Luft H. Zusammenhänge zwischen Hypophysentumor und Schwangerschaft. Zentralbl Gynakol. 1968 Nov 2;90(44):1501–1505. [PubMed] [Google Scholar]
- Thorner M. O., McNeilly A. S., Hagan C., Besser G. M. Long-term treatment of galactorrhoea and hypogonadism with bromocriptine. Br Med J. 1974 May 25;2(5916):419–422. doi: 10.1136/bmj.2.5916.419. [DOI] [PMC free article] [PubMed] [Google Scholar]