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. 1975 Nov 8;4(5992):313–316. doi: 10.1136/bmj.4.5992.313

Absorption and metabolism of nicotine from cigarettes.

A K Armitage, C T Dollery, C F George, T H Houseman, P J Lewis, D M Turner
PMCID: PMC1675218  PMID: 1192046

Abstract

Eight men volunteers each smoked a single cirgarette containing 14C-nicotine and gave arterial blood samples during and for 50 minutes after smoking. The maximum concentration of nicotine in the arterial blood ranged from 31 to 41 mug/l in four regular cigarette smokers who inhaled. Two non-smokers achieved maximum levels of 2 and 4 mug/l. On a separate occasion two of the inhalers received 1 mg. 14C-nicotine in 10 divided doses injected intravenously. In both cases the peak arterial nicotine concentrations bore a similar relationship to the intravenous dose, as did the peak nicotine concentrations to the retained doses during smoking.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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