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. 1995 Nov;61(11):4131–4134. doi: 10.1128/aem.61.11.4131-4134.1995

Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk.

S Teraguchi 1, K Shin 1, T Ogata 1, M Kingaku 1, A Kaino 1, H Miyauchi 1, Y Fukuwatari 1, S Shimamura 1
PMCID: PMC167723  PMID: 8526530

Abstract

Feeding of bovine milk to mice induced a high incidence of bacterial translocation from the intestines to the mesenteric lymph nodes, and the bacteria involved were mainly members of the family Enterobacteriaceae. Supplementation of the milk diet with bovine lactoferrin or a pepsin-generated hydrolysate of bovine lactoferrin resulted in significant suppression of bacterial translocation. Our findings suggest that this ability of lactoferrin to inhibit bacterial translocation may be due to its suppression of bacterial overgrowth in the guts of milk-fed mice.

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Selected References

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