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. 1993 Dec 11;307(6918):1524–1527. doi: 10.1136/bmj.307.6918.1524

Growth in utero and serum cholesterol concentrations in adult life.

D J Barker 1, C N Martyn 1, C Osmond 1, C N Hales 1, C H Fall 1
PMCID: PMC1679540  PMID: 8274921

Abstract

OBJECTIVE--To see whether reduced rates of fetal growth are related to raised serum cholesterol concentrations in adult life. DESIGN--Follow up study of men and women whose size at birth had been recorded. SETTING--Jessop and Northern General Hospitals, Sheffield. SUBJECTS--219 men and women born in the Jessop Hospital during 1939-40. MAIN OUTCOME MEASURES--Serum concentrations of total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B. RESULTS--Men and women who had had a small abdominal circumference at birth had raised serum concentrations of total and low density lipoprotein cholesterol and apolipoprotein B. This was independent of the duration of gestation. Serum concentrations of total cholesterol fell by 0.25 mmol/l (95% confidence interval 0.09 to 0.42) with each 1 in (2.54 cm) increase in abdominal circumference. The corresponding figure for serum low density lipoprotein cholesterol was 0.26 mmol/l (0.11 to 0.42) and for serum apolipoprotein B 0.04 g/l (0.02 to 0.07). Small head and chest circumferences at birth and short length were each associated with raised serum low density lipoprotein cholesterol concentrations but the trends disappeared in a simultaneous regression with abdominal circumference at birth. The association between abdominal circumference at birth and low density lipoprotein cholesterol concentration was independent of social class, current body weight, cigarette smoking, and alcohol consumption. CONCLUSION--Raised serum cholesterol concentrations in adult life are associated with impaired growth during late gestation, when fetal undernutrition has a disproportionate effect on liver growth. Impaired liver growth may permanently alter low density lipoprotein cholesterol metabolism.

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Selected References

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  1. Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
  2. Andersen G. E., Lifschitz C., Friis-Hansen B. Dietary habits and serum lipids during first 4 years of life. A study of 95 Danish children. Acta Paediatr Scand. 1979 Mar;68(2):165–170. doi: 10.1111/j.1651-2227.1979.tb04983.x. [DOI] [PubMed] [Google Scholar]
  3. Barker D. J., Bull A. R., Osmond C., Simmonds S. J. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990 Aug 4;301(6746):259–262. doi: 10.1136/bmj.301.6746.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barker D. J., Gluckman P. D., Godfrey K. M., Harding J. E., Owens J. A., Robinson J. S. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993 Apr 10;341(8850):938–941. doi: 10.1016/0140-6736(93)91224-a. [DOI] [PubMed] [Google Scholar]
  5. Barker D. J., Meade T. W., Fall C. H., Lee A., Osmond C., Phipps K., Stirling Y. Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ. 1992 Jan 18;304(6820):148–152. doi: 10.1136/bmj.304.6820.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Barker D. J., Osmond C., Simmonds S. J., Wield G. A. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ. 1993 Feb 13;306(6875):422–426. doi: 10.1136/bmj.306.6875.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bhatnagar D., Durrington P. N. Clinical value of apolipoprotein measurement. Ann Clin Biochem. 1991 Sep;28(Pt 5):427–437. doi: 10.1177/000456329102800501. [DOI] [PubMed] [Google Scholar]
  8. Campbell S., Thoms A. Ultrasound measurement of the fetal head to abdomen circumference ratio in the assessment of growth retardation. Br J Obstet Gynaecol. 1977 Mar;84(3):165–174. doi: 10.1111/j.1471-0528.1977.tb12550.x. [DOI] [PubMed] [Google Scholar]
  9. Carr B. R., Simpson E. R. Cholesterol synthesis in human fetal tissues. J Clin Endocrinol Metab. 1982 Sep;55(3):447–452. doi: 10.1210/jcem-55-3-447. [DOI] [PubMed] [Google Scholar]
  10. Fall C. H., Barker D. J., Osmond C., Winter P. D., Clark P. M., Hales C. N. Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. BMJ. 1992 Mar 28;304(6830):801–805. doi: 10.1136/bmj.304.6830.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fossati P., Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982 Oct;28(10):2077–2080. [PubMed] [Google Scholar]
  12. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed] [Google Scholar]
  13. Hahn P., Kirby L. Immediate and late effects of premature weaning and of feeding a high fat or high carbohydrate diet to weanling rats. J Nutr. 1973 May;103(5):690–696. doi: 10.1093/jn/103.5.690. [DOI] [PubMed] [Google Scholar]
  14. Hales C. N., Barker D. J., Clark P. M., Cox L. J., Fall C., Osmond C., Winter P. D. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991 Oct 26;303(6809):1019–1022. doi: 10.1136/bmj.303.6809.1019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hassan A. S., Gallon L. S., Yunker R. L., Subbiah M. T. Effect of enhancement of cholesterol catabolism in guinea pigs after weaning on subsequent response to dietary cholesterol. Am J Clin Nutr. 1982 Mar;35(3):546–550. doi: 10.1093/ajcn/35.3.546. [DOI] [PubMed] [Google Scholar]
  16. Innis S. M. Influence of maternal cholestyramine treatment on cholesterol and bile acid metabolism in adult offspring. J Nutr. 1983 Dec;113(12):2464–2470. doi: 10.1093/jn/113.12.2464. [DOI] [PubMed] [Google Scholar]
  17. Jones B., Smith P., Harrison D. Replantation. Br Med J (Clin Res Ed) 1983 Jul 2;287(6384):1–2. doi: 10.1136/bmj.287.6384.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Labarthe D. R., Eissa M., Varas C. Childhood precursors of high blood pressure and elevated cholesterol. Annu Rev Public Health. 1991;12:519–541. doi: 10.1146/annurev.pu.12.050191.002511. [DOI] [PubMed] [Google Scholar]
  19. Lopes-Virella M. F., Stone P., Ellis S., Colwell J. A. Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem. 1977 May;23(5):882–884. [PubMed] [Google Scholar]
  20. McCance R. A., Widdowson E. M. The determinants of growth and form. Proc R Soc Lond B Biol Sci. 1974 Jan 22;185(1078):1–17. doi: 10.1098/rspb.1974.0001. [DOI] [PubMed] [Google Scholar]
  21. McNamara D. J., Quackenbush F. W., Rodwell V. W. Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. Developmental pattern. J Biol Chem. 1972 Sep 25;247(18):5805–5810. [PubMed] [Google Scholar]
  22. Mott G. E., Jackson E. M., McMahan C. A., McGill H. C., Jr Cholesterol metabolism in adult baboons is influenced by infant diet. J Nutr. 1990 Mar;120(3):243–251. doi: 10.1093/jn/120.3.243. [DOI] [PubMed] [Google Scholar]
  23. Osmond C., Barker D. J., Winter P. D., Fall C. H., Simmonds S. J. Early growth and death from cardiovascular disease in women. BMJ. 1993 Dec 11;307(6918):1519–1524. doi: 10.1136/bmj.307.6918.1519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sporik R., Johnstone J. H., Cogswell J. J. Longitudinal study of cholesterol values in 68 children from birth to 11 years of age. Arch Dis Child. 1991 Jan;66(1):134–137. doi: 10.1136/adc.66.1.134. [DOI] [PMC free article] [PubMed] [Google Scholar]

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