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. 1987 Jul;28(7):427–431.

Canine Sertoli Cell Tumor: A Medical Records Search and Literature Review

Klaas Post, Susan H Kilborn
PMCID: PMC1680484  PMID: 17422824

Abstract

Seventeen cases of Sertoli cell tumor in dogs were found by searching medical records from 1971 to 1985. The average age of affected dogs was ten years, and most animals were of mixed breed. Most of the dogs were presented for reasons unrelated to the Sertoli cell tumor, however, most dogs had one or more clinical signs associated with Sertoli cell tumor. These signs included prostatic changes, alopecia and hyperpigmentation, bone marrow suppression, gynecomastia, and behavioral changes. The association of Sertoli cell tumor with cryptorchidism was obvious in these records, as ten of the dogs had one or both testicles undescended. Histopathological features of the tumors were variable and had no consistent correlation with metastatic potential. Some interesting comparisons can be made regarding these tumors in other domestic animals and in man.

Keywords: Sertoli cell tumors, testicular neoplasm, hyperestrogenism

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRODEY R. S., MARTIN J. E. Sertoli cell neoplasms in the dog; the clinicopathological and endocrinological findings in thirtyseven dogs. J Am Vet Med Assoc. 1958 Sep 1;133(5):249–257. [PubMed] [Google Scholar]
  2. COTCHIN E. Testicular neoplasms in dogs. J Comp Pathol. 1960 Apr;70:232–248. doi: 10.1016/s0368-1742(60)80024-0. [DOI] [PubMed] [Google Scholar]
  3. Comhaire F., Mattheeuws D., Vermeulen A. Testosterone and oestradiol in dogs with testicular tumours. Acta Endocrinol (Copenh) 1974 Oct;77(2):408–416. doi: 10.1530/acta.0.0770408. [DOI] [PubMed] [Google Scholar]
  4. DOW C. Testicular tumours in the dog. J Comp Pathol. 1962 Jul;72:247–265. doi: 10.1016/s0368-1742(62)80028-9. [DOI] [PubMed] [Google Scholar]
  5. Edwards D. F. Bone marrow hypoplasia in a feminized dog with a Sertoli cell tumor. J Am Vet Med Assoc. 1981 Mar 1;178(5):494–496. [PubMed] [Google Scholar]
  6. Feldman S., Sreckovic I. Gonadal stromal or sertoli cell tumor. Urology. 1980 May;15(5):516–517. doi: 10.1016/0090-4295(80)90021-7. [DOI] [PubMed] [Google Scholar]
  7. Finazzi M., Cammarata G. Histopathologic observations on Sertoli cell tumors in dog. Tumori. 1981 Oct 31;67(5):391–398. doi: 10.1177/030089168106700501. [DOI] [PubMed] [Google Scholar]
  8. Gabrilove J. L., Freiberg E. K., Leiter E., Nicolis G. L. Feminizing and non-feminizing Sertoli cell tumors. J Urol. 1980 Dec;124(6):757–767. doi: 10.1016/s0022-5347(17)55652-9. [DOI] [PubMed] [Google Scholar]
  9. Herrera L. O., Wilk H., Wills J. S., Lopez G. E. Malignant (androblastoma) Sertoli cell tumor of testes. Urology. 1981 Sep;18(3):287–290. doi: 10.1016/0090-4295(81)90367-8. [DOI] [PubMed] [Google Scholar]
  10. Ladds P. W., Saunders P. J. Sertoli cell tumours in the bull. J Comp Pathol. 1976 Oct;86(4):503–508. doi: 10.1016/0021-9975(76)90059-1. [DOI] [PubMed] [Google Scholar]
  11. Laing E. J., Harari J., Smith C. W. Spermatic cord torsion and Sertoli cell tumor in a dog. J Am Vet Med Assoc. 1983 Oct 15;183(8):879–881. [PubMed] [Google Scholar]
  12. Lipowitz A. J., Schwartz A., Wilson G. P., Ebert J. W. Testicular neoplasms and concomitant clinical changes in the dog. J Am Vet Med Assoc. 1973 Dec 15;163(12):1364–1368. [PubMed] [Google Scholar]
  13. Littleton R., Farah R., Cerny J., Ohorodnik J. Sertoli cell testicular tumors. Urology. 1981 Jun;17(6):557–559. doi: 10.1016/0090-4295(81)90075-3. [DOI] [PubMed] [Google Scholar]
  14. Morin L. J., Loening S. Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature. J Urol. 1975 Sep;114(3):476–480. doi: 10.1016/s0022-5347(17)67062-9. [DOI] [PubMed] [Google Scholar]
  15. Palmer N. C., King A. B., Basrur P. K. Sertoli cell tumor in two related newborn shorthorn calves. Can Vet J. 1980 Nov;21(11):317–319. [PMC free article] [PubMed] [Google Scholar]
  16. Post K. Effects of human chorionic gonadotrophin and castration on plasma gonadal steroid hormones of the dog. Can Vet J. 1982 Mar;23(3):98–101. [PMC free article] [PubMed] [Google Scholar]
  17. Pulley L. T. Sertoli cell tumor. Vet Clin North Am Small Anim Pract. 1979 Feb;9(1):145–150. doi: 10.1016/s0195-5616(79)50014-x. [DOI] [PubMed] [Google Scholar]
  18. Rahaley R. S., Gordon B. J., Leipold H. W., Peter J. E. Sertoli cell tumour in a horse. Equine Vet J. 1983 Jan;15(1):68–70. doi: 10.1111/j.2042-3306.1983.tb01713.x. [DOI] [PubMed] [Google Scholar]
  19. Reif J. S., Brodey R. S. The relationship between cryptorchidism and canine testicular neoplasia. J Am Vet Med Assoc. 1969 Dec 15;155(12):2005–2010. [PubMed] [Google Scholar]
  20. Sherding R. G., Wilson G. P., 3rd, Kociba G. J. Bone marrow hypoplasia in eight dogs with Sertoli cell tumor. J Am Vet Med Assoc. 1981 Mar 1;178(5):497–501. [PubMed] [Google Scholar]
  21. Weaver A. D. Survey with follow-up of 67 dogs with testicular sertoli cell tumours. Vet Rec. 1983 Jul 30;113(5):105–107. doi: 10.1136/vr.113.5.105. [DOI] [PubMed] [Google Scholar]

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