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. 1987 Aug;28(8):497-502, 503-504.

Equine Viral Encephalomyelitis in Canada: A Review of Known and Potential Causes

Delwyn P Keane, Peter B Little
PMCID: PMC1680587  PMID: 17422841

Abstract

Rabies, equine herpesvirus type I, and eastern and western encephalomyelitis viruses, known causes of equine neurological disease, are reviewed with emphasis on epidemiology, pathogenesis, clinical signs, and diagnosis.

Several arboviruses known to be active in Canada and capable of producing neurological disease in humans (Powassan, St. Louis encephalitis, snowshoe hare, and Jamestown Canyon viruses) are discussed as potential causes of encephalomyelitis in horses.

Keywords: Equine, encephalomyelitis, viral, arbovirus

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Artsob H., Wright R., Shipp L., Spence L., Th'ng C. California encephalitis virus activity in mosquitoes and horses in southern Ontario, 1975. Can J Microbiol. 1978 Dec;24(12):1544–1547. doi: 10.1139/m78-246. [DOI] [PubMed] [Google Scholar]
  2. Bagust T. J., Clark L. Pathogenesis of meningo-encephalitis produced in calves by infectious bovine rhinotracheitis herpesvirus. J Comp Pathol. 1972 Oct;82(4):375–383. doi: 10.1016/0021-9975(72)90036-9. [DOI] [PubMed] [Google Scholar]
  3. Bellavance R., Rossier E., Lemaître M., Willis N. G., Bélanger P. Eastern equine encephalomyelitis in Eastern Canada--1972. Can J Public Health. 1973 Mar;64(2):189–190. [PubMed] [Google Scholar]
  4. Bitsch V., Dam A. Nervous disturbances in horses in relation to infection with equine rhinopneumonitis virus. Acta Vet Scand. 1971;12(1):134–136. [PubMed] [Google Scholar]
  5. Blenden D. C. Rabies in a litter of skunks predicted and diagnosed by skin biopsy. J Am Vet Med Assoc. 1981 Oct 15;179(8):789–791. [PubMed] [Google Scholar]
  6. Blythe L. L., Mattson D. E., Lassen E. D., Craig A. M. Antibodies against equine herpesvirus 1 in the cerebrospinal fluid in the horse. Can Vet J. 1985 Jul;26(7):218–220. [PMC free article] [PubMed] [Google Scholar]
  7. Bryans J. T. On immunity to disease caused by equine herpesvirus 1. J Am Vet Med Assoc. 1969 Jul 15;155(2):294–300. [PubMed] [Google Scholar]
  8. Burton A. N., McLintock J., Francy D. B. Isolation of St. Louis encephalitis and Cache Valley viruses from Saskatchewan mosquitoes. Can J Public Health. 1973 Jul-Aug;64(4):368–373. [PubMed] [Google Scholar]
  9. CORNER A. H. PATHOLOGY OF EXPERIMENTAL AUJESZKY'S DISEASE IN PIGLETS. Res Vet Sci. 1965 Jul;6:337–343. [PubMed] [Google Scholar]
  10. Calisher C. H., Emerson J. K., Muth D. J., Lazuick J. S., Monath T. P. Serodiagnosis of western equine encephalitis virus infections: relationships of antibody titer and test to observed onset of clinical illness. J Am Vet Med Assoc. 1983 Aug 15;183(4):438–440. [PubMed] [Google Scholar]
  11. Carmichael L. E. Herpesvirus canis: aspects of pathogenesis and immune response. J Am Vet Med Assoc. 1970 Jun 15;156(12):1714–1721. [PubMed] [Google Scholar]
  12. Charlton K. M., Casey G. A. Experimental rabies in skunks: persistence of virus in denervated muscle at the inoculation site. Can J Comp Med. 1981 Oct;45(4):357–362. [PMC free article] [PubMed] [Google Scholar]
  13. Charlton K. M., Mitchell D., Girard A., Corner A. H. Meningoencephalomyelitis in horses associated with equine herpesvirus 1 infection. Vet Pathol. 1976;13(1):59–68. doi: 10.1177/030098587601300107. [DOI] [PubMed] [Google Scholar]
  14. DILLENBERG H. HUMAN WESTERN EQUINE ENCEPHALOMYELITIS (WEE) IN SASKATCHEWAN. Can J Public Health. 1965 Jan;56:17–20. [PubMed] [Google Scholar]
  15. Dean D. J., Abelseth M. K. Laboratory techniques in rabies: the fluorescent antibody test. Monogr Ser World Health Organ. 1973;(23):73–84. [PubMed] [Google Scholar]
  16. Dinter Z., Klingeborn B. Serological study of an outbreak of paresis due to equid herpesvirus 1 (EHV-1). Vet Rec. 1976 Jul 3;99(1):10–12. doi: 10.1136/vr.99.1.10. [DOI] [PubMed] [Google Scholar]
  17. Edward D. G. Determination of sterol requirement for Mycoplasmatales. J Gen Microbiol. 1971 Dec;69(2):205–210. doi: 10.1099/00221287-69-2-205. [DOI] [PubMed] [Google Scholar]
  18. Feinstone S. M., Mihalik K. B., Kamimura T., Alter H. J., London W. T., Purcell R. H. Inactivation of hepatitis B virus and non-A, non-B hepatitis by chloroform. Infect Immun. 1983 Aug;41(2):816–821. doi: 10.1128/iai.41.2.816-821.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Flamand A., Wiktor T. J., Koprowski H. Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. I. The nucleocapsid protein. J Gen Virol. 1980 May;48(1):97–104. doi: 10.1099/0022-1317-48-1-97. [DOI] [PubMed] [Google Scholar]
  20. Flamand A., Wiktor T. J., Koprowski H. Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein. J Gen Virol. 1980 May;48(1):105–109. doi: 10.1099/0022-1317-48-1-105. [DOI] [PubMed] [Google Scholar]
  21. Fulton J. S. A Report of Two Outbreaks of Equine Encephalomyelitis in Saskatchewan. Can J Comp Med. 1938 Feb;2(2):39–46. [PMC free article] [PubMed] [Google Scholar]
  22. HANSON R. P. An epizootic of equine encephalomyelitis that occurred in Massachusetts in 1831. Am J Trop Med Hyg. 1957 Sep;6(5):858–862. doi: 10.4269/ajtmh.1957.6.858. [DOI] [PubMed] [Google Scholar]
  23. Hammon W. M., Gray J. A., Jr, Evans F. C., Izumi E. M., Lundy H. W. WESTERN EQUINE AND ST. LOUIS ENCEPHALITIS ANTIBODIES IN THE SERA OF MAMMALS AND BIRDS FROM AN ENDEMIC AREA. Science. 1941 Sep 26;94(2439):305–307. doi: 10.1126/science.94.2439.305. [DOI] [PubMed] [Google Scholar]
  24. Jackson T. A., Osburn B. I., Cordy D. R., Kendrick J. W. Equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. Am J Vet Res. 1977 Jun;38(6):709–719. [PubMed] [Google Scholar]
  25. Jackson T., Kendrick J. W. Paralysis of horses associated with equine herpesvirus 1 infection. J Am Vet Med Assoc. 1971 Apr 15;158(8):1351–1357. [PubMed] [Google Scholar]
  26. Johnson R. T. Experimental rabies. Studies of cellular vulnerability and pathogenesis using fluorescent antibody staining. J Neuropathol Exp Neurol. 1965 Oct;24(4):662–674. [PubMed] [Google Scholar]
  27. KISSLING R. E., CHAMBERLAIN R. W., EIDSON M. E., SIKES R. K., BUCCA M. A. Studies on the North American arthropod-borne encephalitides. II. Eastern equine encephalitis in horses. Am J Hyg. 1954 Nov;60(3):237–250. doi: 10.1093/oxfordjournals.aje.a119717. [DOI] [PubMed] [Google Scholar]
  28. KISSLING R. E., RUBIN H. Pathology of eastern equine encephalomyelitis. Am J Vet Res. 1951 Apr;12(43):100–105. [PubMed] [Google Scholar]
  29. Karabatsos N. Supplement to International Catalogue of Arboviruses including certain other viruses of vertebrates. Am J Trop Med Hyg. 1978 Mar;27(2 Pt 2 Suppl):372–440. doi: 10.4269/ajtmh.1978.27.372. [DOI] [PubMed] [Google Scholar]
  30. Lillie L. E., Wong F. C., Drysdale R. A. Equine epizootic of western encephalomyelitis in Manitoba-1975. Can J Public Health. 1976 May-Jun;67 (Suppl 1):21–27. [PubMed] [Google Scholar]
  31. Little P. B., Thorsen J. Disseminated necrotizing myeloencephalitis: a herpes-associated neurological disease of horses. Vet Pathol. 1976;13(3):161–171. doi: 10.1177/030098587601300301. [DOI] [PubMed] [Google Scholar]
  32. Little P. B., Thorsen J., Moore W., Weninger N. Powassan viral encephalitis: a review and experimental studies in the horse and rabbit. Vet Pathol. 1985 Sep;22(5):500–507. doi: 10.1177/030098588502200510. [DOI] [PubMed] [Google Scholar]
  33. Lynch J. A., Binnington B. D., Artsob H. California serogroup virus infection in a horse with encephalitis. J Am Vet Med Assoc. 1985 Feb 15;186(4):389–389. [PubMed] [Google Scholar]
  34. McLEAN D. M., DONOHUE W. L. Powassan virus: isolation of virus from a fatal case of encephalitis. Can Med Assoc J. 1959 May 1;80(9):708–711. [PMC free article] [PubMed] [Google Scholar]
  35. McLintock J. The arbovirus problem in Canada. Can J Public Health. 1976 May-Jun;67 (Suppl 1):8–12. [PubMed] [Google Scholar]
  36. Meyer K. F., Haring C. M., Howitt B. THE ETIOLOGY OF EPIZOOTIC ENCEPHALOMYELITIS OF HORSES IN THE SAN JOAQUIN VALLEY, 1930. Science. 1931 Aug 28;74(1913):227–228. doi: 10.1126/science.74.1913.227. [DOI] [PubMed] [Google Scholar]
  37. Monath T. P., McLean R. G., Cropp C. B., Parham G. L., Lazuick J. S., Calisher C. H. Diagnosis of eastern equine encephalomyelitis by immunofluorescent staining of brain tissue. Am J Vet Res. 1981 Aug;42(8):1418–1421. [PubMed] [Google Scholar]
  38. Morgante O., Vance H. N., Shemanchuk J. A., Windsor R. Epizootic of western encephalomyelitis virus infection in equines in Alberta in 1965. Can J Comp Med. 1968 Apr;32(2):403–408. [PMC free article] [PubMed] [Google Scholar]
  39. Murphy F. A., Bauer S. P., Harrison A. K., Winn W. C., Jr Comparative pathogenesis of rabies and rabies-like viruses. Viral infection and transit from inoculation site to the central nervous system. Lab Invest. 1973 Mar;28(3):361–376. [PubMed] [Google Scholar]
  40. Murphy F. A., Harrison A. K., Winn W. C., Bauer S. P. Comparative pathogenesis of rabies and rabies-like viruses: infection of the central nervous system and centrifugal spread of virus to peripheral tissues. Lab Invest. 1973 Jul;29(1):1–16. [PubMed] [Google Scholar]
  41. Percy D. H., Olander H. J., Carmichael L. E. Encephalitis in the newborn pup due to a canine herpesvirus. Pathol Vet. 1968;5(2):135–145. doi: 10.1177/030098586800500205. [DOI] [PubMed] [Google Scholar]
  42. Platt H., Singh H., Whitwell K. E. Pathological observations on an outbreak of paralysis in broodmares. Equine Vet J. 1980 Jul;12(3):118–126. doi: 10.1111/j.2042-3306.1980.tb03398.x. [DOI] [PubMed] [Google Scholar]
  43. Smith W. B., Blenden D. C., Fuh T. H., Hiler L. Diagnosis of rabies by immunofluorescent staining of frozen sections of skin. J Am Vet Med Assoc. 1972 Dec 1;161(11):1495–1501. [PubMed] [Google Scholar]
  44. Sponseller M. L., Binn L. N., Wooding W. L., Yager R. H. Field strains of western encephalitis virus in ponies: virologic, clinical, and pathologic observations. Am J Vet Res. 1966 Nov;27(121):1591–1598. [PubMed] [Google Scholar]
  45. Tabel H., Charlton K. M. The diagnosis of rabies in a horse by brain neutralization test. Can J Comp Med. 1974 Jul;38(3):344–346. [PMC free article] [PubMed] [Google Scholar]
  46. Thein P. Infection of the central nervous system of horses with equine herpesvirus serotype 1. J S Afr Vet Assoc. 1981 Sep;52(3):239–241. [PubMed] [Google Scholar]
  47. Thomson G. W., McCready R., Sanford E., Gagnon A. Case report: An outbreak of herpesvirus myeloencephalitis in vaccinated horses. Can Vet J. 1979 Jan;20(1):22–25. [PMC free article] [PubMed] [Google Scholar]
  48. Thorsen J., Little P. B. Isolation of equine herpesvirus type 1 from a horse with an acute paralytic disease. Can J Comp Med. 1975 Jul;39(3):358–359. [PMC free article] [PubMed] [Google Scholar]
  49. Tierkel E. S. Laboratory techniques in rabies: rapid microscopic examination for Negri bodies and preparation of specimens for biological test. Monogr Ser World Health Organ. 1973;(23):41–55. [PubMed] [Google Scholar]
  50. Westaway E. G., Brinton M. A., Gaidamovich SYa, Horzinek M. C., Igarashi A., Käriäinen L., Lvov D. K., Porterfield J. S., Russell P. K., Trent D. W. Flaviviridae. Intervirology. 1985;24(4):183–192. doi: 10.1159/000149642. [DOI] [PubMed] [Google Scholar]

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