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. 1989 Oct;30(10):816–822.

The Haemophilus somnus disease complex (Hemophilosis): A review

Frederick W Harris, Eugene D Janzen
PMCID: PMC1681297  PMID: 17423440

Abstract

Haemophilus somnus has long been associated with thrombotic meningoencephalomyelitis but has also been identified as the agent responsible for other clinical diseases including respiratory disease, reproductive problems, myocarditis, otitis, conjunctivitis, mastitis, and polyarthritis. Exposure to the bacteria is widespread and infection may occur via the respiratory tract from urogenital excretions and secretions.

Diagnosis and treatment of hemophilosis may be easy or difficult depending on the manifestation presented, and special procedures must be taken to facilitate isolation of the organism. Satisfactory control measures are not available; vaccination is the only preventive measure demonstrating a beneficial effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames T. R. Neurologic disease caused by Haemophilus somnus. Vet Clin North Am Food Anim Pract. 1987 Mar;3(1):61–73. doi: 10.1016/s0749-0720(15)31179-8. [DOI] [PubMed] [Google Scholar]
  2. Andrews J. J., Anderson T. D., Slife L. N., Stevenson G. W. Microscopic lesions associated with the isolation of Haemophilus somnus from pneumonic bovine lungs. Vet Pathol. 1985 Mar;22(2):131–136. doi: 10.1177/030098588502200206. [DOI] [PubMed] [Google Scholar]
  3. Armstrong K. R., Osborne A. D., Janzen E. D. Haemophilus somnus Mastitis in a Dairy Cow. Can Vet J. 1986 May;27(5):211–212. [PMC free article] [PubMed] [Google Scholar]
  4. BROWN W. W., GRINER L. A., JENSEN R. Infectious embolic meningo-encephalitis in cattle. J Am Vet Med Assoc. 1956 Nov 1;129(9):417–421. [PubMed] [Google Scholar]
  5. Bailie W. E., Anthony H. D., Weide K. D. Infectious thromboembolic meningoencephalomyelitis (sleeper syndrome) in feedlot cattle. J Am Vet Med Assoc. 1966 Jan 15;148(2):162–166. [PubMed] [Google Scholar]
  6. Beveridge T. J. Bacterial structure and its implications in the mechanisms of infection: a short review. Can J Microbiol. 1980 Jun;26(6):643–653. doi: 10.1139/m80-113. [DOI] [PubMed] [Google Scholar]
  7. Brewer R. A., Corbel M. J., Stuart F. A. Development of improved methods for the transport and isolation of Haemophilus somnus. Res Vet Sci. 1985 Nov;39(3):299–306. [PubMed] [Google Scholar]
  8. Chladek D. W. Bovine abortion associated with Haemophilus somnus. Am J Vet Res. 1975 Jul;36(7):1041–1041. [PubMed] [Google Scholar]
  9. Corboz L., Nicolet J. Infektionen mit sogenannten "Haemophilus somnus" beim Rind: Isolierung und Charakterisierung von Stämmen aus Respirations-und Geschlechtsorganen. Schweiz Arch Tierheilkd. 1975 Sep;117(9):493–502. [PubMed] [Google Scholar]
  10. Corboz L., Pohlenz J. Experimentelle Infektionen mit sogenanntem Haemophilus somnus beim Kalb: Vergleich von Stämmen mit unterschiedlicher Virulenz. Schweiz Arch Tierheilkd. 1976 Oct;118(10):429–440. [PubMed] [Google Scholar]
  11. Corboz L., Wild P. Epidemiologie der Haemophilus somnus-Infektion beim Rind: Vergleich von Stämmen in der Polyacrylamidgel-Elektrophorese (PAGE). Schweiz Arch Tierheilkd. 1981 Feb;123(2):79–88. [PubMed] [Google Scholar]
  12. Costerton J. W., Ingram J. M., Cheng K. J. Structure and function of the cell envelope of gram-negative bacteria. Bacteriol Rev. 1974 Mar;38(1):87–110. doi: 10.1128/br.38.1.87-110.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Dewey K. J., Little P. B. Environmental survival of Haemophilus somnus and influence of secretions and excretions. Can J Comp Med. 1984 Jan;48(1):23–26. [PMC free article] [PubMed] [Google Scholar]
  14. Garcia-Delgado G. A., Little P. B., Barnum D. A. A comparison of various Haemophilus somnus strains. Can J Comp Med. 1977 Oct;41(4):380–388. [PMC free article] [PubMed] [Google Scholar]
  15. Groom S. C., Little P. B. Effects of vaccination of calves against induced Haemophilus somnus pneumonia. Am J Vet Res. 1988 Jun;49(6):793–800. [PubMed] [Google Scholar]
  16. Groom S. C., Little P. B., Rosendal S. Virulence differences among three strains of Haemophilus somnus following intratracheal inoculation of calves. Can J Vet Res. 1988 Jul;52(3):349–354. [PMC free article] [PubMed] [Google Scholar]
  17. Guichon P. T., Pritchard J., Jim G. K. Haemophilus somnus myocarditis in a feedlot steer. Can Vet J. 1988 Dec;29(12):1012–1013. [PMC free article] [PubMed] [Google Scholar]
  18. Hall R. F., Williams J. M., Smith G. L. Field evaluation of Haemophilus somnus bacterin. Vet Med Small Anim Clin. 1977 Aug;72(8):1368–1370. [PubMed] [Google Scholar]
  19. Hazlett M. J., Little P. B., Barnum D. A. Experimental Production of Mastitis with Haemophilus somnus in the Lactating Bovine Mammary Gland. Can Vet J. 1983 Apr;24(4):135–136. [PMC free article] [PubMed] [Google Scholar]
  20. Higgins R., Martin J. R., Larouche Y., Goyette G. Mastitis Caused by Haemophilus somnus in a Dairy Cow. Can Vet J. 1987 Mar;28(3):117–119. [PMC free article] [PubMed] [Google Scholar]
  21. Hoerlein A. B., Goto K., Young S. Haemophilus somnus agglutinins in cattle. J Am Vet Med Assoc. 1973 Dec 15;163(12):1375–1377. [PubMed] [Google Scholar]
  22. Humphrey J. D., Little P. B., Barnum D. A., Doig P. A., Stephens L. R., Thorsen J. Occurrence of "Haemophilus somnus" in bovine semen and in the prepuce of bulls and steers. Can J Comp Med. 1982 Apr;46(2):215–217. [PMC free article] [PubMed] [Google Scholar]
  23. Humphrey J. D., Little P. B., Stephens L. R., Barnum D. A., Doig P. A., Thorsen J. Prevalence and distribution of Haemophilus somnus in the male bovine reproductive tract. Am J Vet Res. 1982 May;43(5):791–795. [PubMed] [Google Scholar]
  24. KENNEDY P. C., BIBERSTEIN E. L., HOWARTH J. A., FRAZIER L. M., DUNGWORTH D. L. Infectious meningo-encephalitis in cattle, caused by a haemophilus-like organism. Am J Vet Res. 1960 Mar;21:403–409. [PubMed] [Google Scholar]
  25. Kaneene J. B., Coe P. H., Gibson C. D., Yamini B., Marinez R. O., Morrow D. A. The role of Haemophilus somnus in early embryonic death. I. The effect of the organism on embryos by day 8 postbreeding. Theriogenology. 1986 Aug;26(2):189–198. doi: 10.1016/0093-691x(86)90023-3. [DOI] [PubMed] [Google Scholar]
  26. Kaneene J. B., Coe P. H., Gibson C. D., Yamini B., Morrow D. A., Marinez R. O. The role of Haemophilus somnus in bovine early embryonic death. III. The effect of the organism on embryos by day 21 postbreeding. Theriogenology. 1987 May;27(5):737–749. doi: 10.1016/0093-691x(87)90296-2. [DOI] [PubMed] [Google Scholar]
  27. Lamont H. H., Hunt B. W. Haemophilus somnus and conjunctivitis. Vet Rec. 1982 Jul 3;111(1):21–21. doi: 10.1136/vr.111.1.21. [DOI] [PubMed] [Google Scholar]
  28. Lancaster M. J., McGillivery D. J., Patterson R. M., Irwin S. Pneumonia associated with Haemophilus somnus in a calf. Aust Vet J. 1984 Aug;61(8):269–269. doi: 10.1111/j.1751-0813.1984.tb15545.x. [DOI] [PubMed] [Google Scholar]
  29. Little P. B. Haemophilus somnus Complex: Pathogenesis of the Septicemic Thrombotic Meningoencephalitis. Can Vet J. 1986 Feb;27(2):94–96. [PMC free article] [PubMed] [Google Scholar]
  30. Little P. B., Sorensen D. K. Bovine polioencephalomalacia, infectious embolic meningoencephalitis, and acute lead poisoning in feedlot cattle. J Am Vet Med Assoc. 1969 Dec 15;155(12):1892–1903. [PubMed] [Google Scholar]
  31. Luginbühl A., Küpfer U. Bakteriologische Befunde im Geschlechtsapparat von Kühen im Puerperium. II: Beziehungen zu Uterusinvolution, Ovaraktivität, Beschaffenheit des Cervicalschleims und Fruchtbarkeit. Schweiz Arch Tierheilkd. 1980 Dec;122(12):695–705. [PubMed] [Google Scholar]
  32. Martin S. W., Meek A. H., Davis D. G., Johnson J. A., Curtis R. A. Factors associated with morbidity and mortality in feedlot calves: the Bruce County beef project, year two. Can J Comp Med. 1981 Apr;45(2):103–112. [PMC free article] [PubMed] [Google Scholar]
  33. Martin S. W., Meek A. H., Davis D. G., Johnson J. A., Curtis R. A. Factors associated with mortality and treatment costs in feedlot calves: the Bruce County Beef Project, years 1978, 1979, 1980. Can J Comp Med. 1982 Oct;46(4):341–349. [PMC free article] [PubMed] [Google Scholar]
  34. Martin S. W., Meek A. H., Davis D. G., Thomson R. G., Johnson J. A., Lopez A., Stephens L., Curtis R. A., Prescott J. F., Rosendal S. Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project. Can J Comp Med. 1980 Jan;44(1):1–10. [PMC free article] [PubMed] [Google Scholar]
  35. Miesner A. W. Infectious thromboembolic meningoencephalitis (TEME) in an Iowa feedlot. Vet Med Small Anim Clin. 1978 Sep;73(9):1189–1190. [PubMed] [Google Scholar]
  36. Miller R. B., Lein D. H., McEntee K. E., Hall C. E., Shin S. Haemophilus somnus infection of the reproductive tract of cattle: a review. J Am Vet Med Assoc. 1983 Jun 15;182(12):1390–1392. [PubMed] [Google Scholar]
  37. Nation P. N., Frelier P. F., Gifford G. A., Carnat B. D. Otitis in feedlot cattle. Can Vet J. 1983 Jul;24(7):238–238. [PMC free article] [PubMed] [Google Scholar]
  38. Panciera R. J., Dahlgren R. R., Rinker H. B. Observations on septicemia of cattle caused by a haemophilus-like organism. Pathol Vet. 1968;5(3):212–216. doi: 10.1177/030098586800500303. [DOI] [PubMed] [Google Scholar]
  39. Patterson R. M., Hill J. F., Shiel M. J., Humphrey J. D. Isolation of Haemophilus somnus from vaginitis and cervicitis in dairy cattle. Aust Vet J. 1984 Sep;61(9):301–302. doi: 10.1111/j.1751-0813.1984.tb06022.x. [DOI] [PubMed] [Google Scholar]
  40. Potgieter L. N., Helman R. G., Greene W., Breider M. A., Thurber E. T., Peetz R. H. Experimental bovine respiratory tract disease with Haemophilus somnus. Vet Pathol. 1988 Mar;25(2):124–130. doi: 10.1177/030098588802500204. [DOI] [PubMed] [Google Scholar]
  41. Radostits O. M., Janzen E., Doige C., Jim K. Alberta. Mycoplasma arthritis in feedlot cattle. Can Vet J. 1988 Jun;29(6):531–532. [PMC free article] [PubMed] [Google Scholar]
  42. Ribble C. S., Jim G. K., Janzen E. D. Efficacy of immunization of feedlot calves with a commercial Haemophilus somnus bacterin. Can J Vet Res. 1988 Apr;52(2):191–198. [PMC free article] [PubMed] [Google Scholar]
  43. Ruegg P. L., Marteniuk J. V., Kaneene J. B. Reproductive difficulties in cattle with antibody titers to Haemophilus somnus. J Am Vet Med Assoc. 1988 Oct 15;193(8):941–942. [PubMed] [Google Scholar]
  44. Sanfaçon D., Higgins R. Epidemiology of Haemophilus somnus infection in dairy cattle in Quebec. Can J Comp Med. 1983 Oct;47(4):456–459. [PMC free article] [PubMed] [Google Scholar]
  45. Sauders J. R., Saunders J. R., Osborne A. D. Prevalence of haemophilus somnus in the semen of bulls in Saskatchewan. Can Vet J. 1981 Nov;22(11):361–362. [PMC free article] [PubMed] [Google Scholar]
  46. Saunders J. R., Janzen E. D. Haemophilus somnus infections. II. A Canadian field trial of a commercial bacterin: clinical and serological results. Can Vet J. 1980 Aug;21(8):219–224. [PMC free article] [PubMed] [Google Scholar]
  47. Saunders J. R., Thiessen W. A., Janzen E. D. Haemophilus somnus infections I. A ten year (1969-1978) retrospective study of losses in cattle herds in Western Canada. Can Vet J. 1980 Apr;21(4):119–123. [PMC free article] [PubMed] [Google Scholar]
  48. Simonson R. R., Maheswaran S. K. Host humoral factors in natural resistance to Haemophilus somnus. Am J Vet Res. 1982 Jul;43(7):1160–1164. [PubMed] [Google Scholar]
  49. Smith H. Microbial surfaces in relation to pathogenicity. Bacteriol Rev. 1977 Jun;41(2):475–500. doi: 10.1128/br.41.2.475-500.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Stephens L. R., Little P. B., Humphrey J. D., Wilkie B. N., Barnum D. A. Vaccination of cattle against experimentally induced thromboembolic meningoencephalitis with a Haemophilus somnus bacterin. Am J Vet Res. 1982 Aug;43(8):1339–1342. [PubMed] [Google Scholar]
  51. Stephens L. R., Little P. B. Ultrastructure of Haemophilus somnus, causative agent of bovine infectious thromboembolic meningoencephalitis. Am J Vet Res. 1981 Sep;42(9):1638–1640. [PubMed] [Google Scholar]
  52. Stephens L. R., Little P. B., Wilkie B. N., Barnum D. A. Humoral immunity in experimental thromboembolic meningoencephalitis in cattle caused by Haemophilus somnus. Am J Vet Res. 1981 Mar;42(3):468–473. [PubMed] [Google Scholar]
  53. Stephens L. R., Little P. B., Wilkie B. N., Barnum D. A. Infectious thromboembolic meningoencephalitis in cattle: a review. J Am Vet Med Assoc. 1981 Feb 15;178(4):378–384. [PubMed] [Google Scholar]
  54. Stephens L. R., Slee K. J., Poulton P., Larcombe M., Kosior E. Investigation of purulent vaginal discharge in cows, with particular reference to Haemophilus somnus. Aust Vet J. 1986 Jun;63(6):182–185. doi: 10.1111/j.1751-0813.1986.tb02969.x. [DOI] [PubMed] [Google Scholar]
  55. Sugimoto C., Mitani K., Nakazawa M., Sekizaki T., Terakado N., Isayama Y. In vitro susceptibility of Haemophilus somnus to 33 antimicrobial agents. Antimicrob Agents Chemother. 1983 Jan;23(1):163–165. doi: 10.1128/aac.23.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Thompson K. G., Little P. B. Effect of Haemophilus somnus on bovine endothelial cell in organ culture. Am J Vet Res. 1981 May;42(5):748–754. [PubMed] [Google Scholar]
  57. Thomson M. S., Stringfellow D. A., Lauerman L. H. Adherence of Haemophilus somnus to bovine embryos after in vitro exposure. Am J Vet Res. 1988 Jan;49(1):63–66. [PubMed] [Google Scholar]
  58. Waldhalm D. G., Hall R. F., Meinershagen W. A., Card C. S., Frank F. W. Haemophilus somnus infection in the cow as a possible contributing factor to weak calf syndrome: isolation and animal inoculation studies. Am J Vet Res. 1974 Nov;35(11):1401–1403. [PubMed] [Google Scholar]
  59. Williams J. M., Smith G. L., Murdock F. M. Immunogenicity of a Haemophilus somnus bacterin in cattle. Am J Vet Res. 1978 Nov;39(11):1756–1762. [PubMed] [Google Scholar]
  60. van Dreumel A. A., Kierstead M. Abortion associated with Hemophilus somnus infection in a bovine fetus. Can Vet J. 1975 Dec;16(12):367–370. [PMC free article] [PubMed] [Google Scholar]

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