Abstract
A patient with chronic myelocytic leukaemia positive for the Philadelphia (Ph-1) chromosome underwent splenectomy in the "terminal phase" of his disease. Chromosomal analysis of a marrow aspirate obtained during the operation showed nothing abnormal. Material from the spleen, however, showed the absence of a C chromosome and the presence of a "marker" chromosome in all metaphases examined. The patient did well for almost three years after splenectomy, and serial cytogenetic studies of marrow specimens showed the Ph-1 chromosome to be the only significant abnormality. Six months before death from recurrent blastic transformation aneuploidy was found in a marrow specimen. Subsequently additional abnormalities, including cells with two Ph-1 chromosomes, were detected. The karyotypic abnormalities found in the splenic specimen, however, never recurred.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Canellos G. P., DeVita V. T., Whang-Peng J., Carbone P. P. Hematologic and cytogenetic remission of blastic transformation in chronic granulocytic leukemia. Blood. 1971 Dec;38(6):671–679. [PubMed] [Google Scholar]
- Duvall C. P., Carbone P. P., Bell W. R., Whang J., Tjio J. H., Perry S. Chronic myelocytic leukemia with two Philadelphia chromosomes and prominent peripheral lymphadenopathy. Blood. 1967 Apr;29(4 Suppl):652–656. [PubMed] [Google Scholar]
- Gibson O. M., Burgess M. A., Stanley L. G. Cytogenetic remission in acute transformation of chronic granulocytic leukaemia. Br Med J. 1969 May 31;2(5656):556–556. doi: 10.1136/bmj.2.5656.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Han T., Ezdinli E. Z., Sokal J. E. Complete remission in chronic lymphocytic leukemia and leukolymphosarcoma. Cancer. 1967 Feb;20(2):243–253. doi: 10.1002/1097-0142(1967)20:2<243::aid-cncr2820200210>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
- Lawler S. D., Galton D. A. Chromosome changes in the terminal stages of chronic granulocytic leukaemia. Acta Med Scand Suppl. 1966;445:312–318. doi: 10.1111/j.0954-6820.1966.tb02377.x. [DOI] [PubMed] [Google Scholar]
- Sokal J. E., Aungst C. W., Grace J. T., Jr Immunotherapy of chronic myelocytic leukemia. Natl Cancer Inst Monogr. 1973 Dec;39:195–198. [PubMed] [Google Scholar]
- Spiers A. S., Baikie A. G. Chronic granulocytic leukaemia: demonstration of the Philadelphia chromosome in cultures of spleen cells. Nature. 1965 Oct 30;208(5009):497–497. doi: 10.1038/208497a0. [DOI] [PubMed] [Google Scholar]
- Whang-Peng J., Canellos G. P., Carbone P. P., Tjio J. H. Clinical implications of cytogenetic variants in chronic myelocytic leukemia (CML). Blood. 1968 Nov;32(5):755–766. [PubMed] [Google Scholar]