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. 1996 Nov;62(11):4206–4209. doi: 10.1128/aem.62.11.4206-4209.1996

Degradation of the fluoroquinolone enrofloxacin by wood-rotting fungi.

R Martens 1, H G Wetzstein 1, F Zadrazil 1, M Capelari 1, P Hoffmann 1, N Schmeer 1
PMCID: PMC168242  PMID: 8900012

Abstract

The veterinary fluoroquinolone enrofloxacin was degraded in vitro by four species of wood-rotting fungi growing on wetted wheat straw containing carbonyl-14C-labeled drug. A maximum 14CO2 production of 17% per week was observed with the brown rot fungus Gloeophyllum striatum, resulting in up to 53% after 8 weeks. However, rates reached at most 0.2 and 0.9% per week, if enrofloxacin was preadsorbed to native or gamma ray-sterilized soil, respectively.

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Selected References

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  1. Barr D. P., Aust S. D. Pollutant degradation by white rot fungi. Rev Environ Contam Toxicol. 1994;138:49–72. doi: 10.1007/978-1-4612-2672-7_3. [DOI] [PubMed] [Google Scholar]
  2. Bumpus J. A., Tien M., Wright D., Aust S. D. Oxidation of persistent environmental pollutants by a white rot fungus. Science. 1985 Jun 21;228(4706):1434–1436. doi: 10.1126/science.3925550. [DOI] [PubMed] [Google Scholar]
  3. Ng E. Y., Trucksis M., Hooper D. C. Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother. 1996 Aug;40(8):1881–1888. doi: 10.1128/aac.40.8.1881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Wicklow D. T., Detroy R. W., Jessee B. A. Decomposition of Lignocellulose by Cyathus stercoreus (Schw.) de Toni NRRL 6473, a "White Rot" Fungus from Cattle Dung. Appl Environ Microbiol. 1980 Jul;40(1):169–170. doi: 10.1128/aem.40.1.169-170.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Wolfson J. S., Hooper D. C. Fluoroquinolone antimicrobial agents. Clin Microbiol Rev. 1989 Oct;2(4):378–424. doi: 10.1128/cmr.2.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]

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