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. 1992 Jan;50(1):56–64.

Mapping of 262 DNA markers into 24 intervals on human chromosome 11.

A Tanigami 1, T Tokino 1, S Takiguchi 1, M Mori 1, T Glaser 1, J W Park 1, C Jones 1, Y Nakamura 1
PMCID: PMC1682531  PMID: 1346079

Abstract

We have extended our mapping effort on human chromosome 11 to encompass a total of 262 DNA markers, which have been mapped into 24 intervals on chromosome 11; 123 of the markers reveal RFLPs. These clones are scattered throughout the chromosome, although some clustering occurs in R-positive bands (p15.1, p11.2, q13, and q23.3). Fifty-two of the markers were found to contain DNA sequences conserved in Chinese hamster, and some of these 52 also cross-hybridized with DNA from other mammals and/or chicken. As the length of chromosome 11 is estimated at nearly 130 cM, the average distance between RFLP markers is roughly 1 cM. The large panel of DNA markers on our map should contribute to investigations of hereditary diseases on this chromosome, and it will also provide reagents for constructing either fine-scale linkage and physical maps or contig maps of cosmids or yeast artificial chromosomes.

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Selected References

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