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. 1992 May;50(5):1018–1021.

Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.

D Jenkins 1, M A Penny 1, Y Uchigata 1, K H Jacobs 1, C H Mijovic 1, Y Hirata 1, T Otani 1, J Fletcher 1, A R Bradwell 1, A H Barnett 1
PMCID: PMC1682608  PMID: 1349195

Abstract

Previous studies have shown that insulin-dependent diabetes mellitus is positively associated with HLA-DR4 and HLA-DR9 in Japanese populations. It was proposed that susceptibility to the disease is determined by a single HLA allele associated with both DR4 and DR9. DR genotypes in a Japanese population with insulin-dependent diabetes mellitus were determined by DRB/DQB RFLP analysis. A single disease-susceptibility-allele model was tested by the antigen-genotype-frequency-among-patients method. Recessive and additive inheritance of a single susceptibility allele were rejected. The DR9-associated disease-susceptibility allele in Japanese subjects is distinct from both the DR3- and DR4-associated susceptibility alleles in white Caucasians. The data suggest further complexity in the inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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