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. 1989 Sep;45(3):368–372.

Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.

T Grimm 1, B Müller 1, M Dreier 1, E Kind 1, T Bettecken 1, G Meng 1, C R Müller 1
PMCID: PMC1683399  PMID: 2570527

Abstract

The DMD gene, which spans more than 2,000 kbp, has been assigned to band Xp21 of the X chromosome. Two subclones (PERT 87-1 and PERT 87-15) of the intragenic locus DXS164 physically are separated by approximately 60 kbp. Linkage studies were done in 49 informative DMD families by using the LINKAGE program. Crossing-over between the loci studied occurred in four families. A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 (support interval 14-135-fold) times higher than expected, was found with a maximum lod score of 13.50. These data suggest a hot spot for recombination within DXS164.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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