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. 1989 Oct;45(4):541–546.

Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease.

H Payami 1, S Joe 1, N R Farid 1, V Stenszky 1, S H Chan 1, P P Yeo 1, J S Cheah 1, G Thomson 1
PMCID: PMC1683504  PMID: 2491013

Abstract

A method is described to reveal the relative predispositional effects (RPEs) (predisposing, protective, or neutral) of the HLA alleles or of any other marker system that is associated with a disease. When the disease is associated with two or more alleles of a locus, the RPE method identifies the associations sequentially according to their strength; thus the problem that a strong association with one allele can create misleading deviations in the frequencies of other alleles is alleviated. Using this method, we have examined the relative effects of HLA-DR alleles in susceptibility to Graves disease in the Caucasian population. The well-established positive association with DR3 was confirmed as the strongest effect. In addition, a negative association was found between DR5 and Graves disease. The reduced frequency of DR5 among patients is statistically significant and is not a result of the increase in DR3. Finally, when patients were divided according to the presence or absence of eye disease, the latter showed a significant increase in the frequency of DR4. With family data, linkage to HLA of Graves disease was established in both Caucasian and Chinese families by the sib-pair method.

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Selected References

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