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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1990 Apr;46(4):789–794.

The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene.

P Concannon 1, U Malhotra 1, P Charmley 1, J Reynolds 1, K Lange 1, R A Gatti 1
PMCID: PMC1683674  PMID: 1969227

Abstract

We have studied the segregation of an RFLP detected with a human ETS-1 genomic probe in 25 families containing members affected with ataxia-telangiectasia (AT) and in 27 families from the Centre d'Etude du Polymorphisme Humain (CEPH) panel. We have recently mapped a gene for AT to 11q22-23 by linkage to the markers THY1 and D11S144. Multipoint linkage analysis of the CEPH families indicated that ETS-1 is located on chromosome 11q approximately 19.2 centimorgans telomeric to THY1. Analysis of the segregation of ETS-1 alleles in AT families yields strongly negative LOD scores, excluding an AT gene from a region extending 15 cM to either side of ETS-1. Multipoint mapping of ETS-1, D11S144, THY1, and AT also excludes the possibility that an AT gene is telomeric to ETS-1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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