Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1990 Aug;47(2):294–301.

Participation of Indo-European tribes in ethnogeny of the mongoloid population of Siberia: analysis of the HLA antigen distribution in mongoloids of Siberia.

V V Fefelova 1
PMCID: PMC1683723  PMID: 2378354

Abstract

Three hundred forty-three Yakuts (mongoloids of central Asian type living in Siberia) were tested for HLA-A, -B, and -C loci. The HLA antigen distribution corresponds on the whole to a mongoloid population with high frequency of the HLA-A9, -B15, and -B40 antigens (phenotype frequencies .533, .367, and .405, respectively). At the same time a strikingly high frequency for the "Indo-European" HLA-A1 antigen (phenotype frequency .282) was detected, which in Yakuts is found exclusively with HLA-B17 (haplotype frequency x 1,000 = 87.0; linkage disequilibrium value x 1,000 = 63.8). The present paper deals with a new hypothesis of the Yakut ethnogenesis according to which ancient Aryan tribes formed the substratum which was later assimilated by the mongoloid and Turkic populations. Another hypothesis that I have advanced argues that from analysis of the HLA system the ancient Aryans formed, a local group within the Indo-European entity, with high frequency for HLA-A1 and -B17 antigens and for the HLA-A1,B17 haplotype and with a complete absence of or very low frequency for the HLA-B8 antigen and for the HLA-A1,B8 haplotype. Significant linkage disequilibrium, as it is found in Indians and Yakuts, etc., could have resulted from mixing of the Aryans with non-Indo-European tribes. No significant linkage disequilibrium between A1 and B8 characteristic of the European caucasoids was produced in the mixing.

Full text

PDF
294

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black F. L. Interrelationships between Amerindian tribes of lower Amazonia as manifest by HLA haplotype disequilibria. Am J Hum Genet. 1984 Nov;36(6):1318–1331. [PMC free article] [PubMed] [Google Scholar]
  2. Bodmer W. F., Bodmer J. G. Evolution and function of the HLA system. Br Med Bull. 1978 Sep;34(3):309–316. doi: 10.1093/oxfordjournals.bmb.a071518. [DOI] [PubMed] [Google Scholar]
  3. Bonné-Tamir B., Bodmer J. G., Bodmer W. F., Pickbourne P., Brautbar C., Gazit E., Nevo S., Zamir R. HLA polymorphism in Israel. 9. An overall comparative analysis. Tissue Antigens. 1978 Mar;11(3):235–250. doi: 10.1111/j.1399-0039.1978.tb01255.x. [DOI] [PubMed] [Google Scholar]
  4. Horai S., Omoto K., Juji T., Sonozaki H., Mitsui H., Misawa S., Sumpaico J. S., Mercado A. S. The HLA antigens of two Negrito populations in the Philippines. Tissue Antigens. 1981 Mar;17(3):343–348. doi: 10.1111/j.1399-0039.1981.tb00710.x. [DOI] [PubMed] [Google Scholar]
  5. Iványi P., Egorov I. K., Pellar L., Malenko A. F., Bavorová H., Forejt J., Hinzovà E., Hronková J., Iványi D., Ivasková E. HLA antigens in three Siberian populations. Tissue Antigens. 1976 Oct;8(4):239–246. [PubMed] [Google Scholar]
  6. Jaraquemada D., Alonso A., Awad J., D'Amaro J., Ollier W., Doyle P., Okoye R. C., Williams E., Festenstein H., Lian F. HLA polymorphisms in a Shanghai Chinese population. Tissue Antigens. 1984 Jan;23(1):23–32. doi: 10.1111/j.1399-0039.1984.tb00004.x. [DOI] [PubMed] [Google Scholar]
  7. Kostyu D., Dawson D., Ciftan E., Stewart A., Lewis D., Parc F., Laigret J., McCollum R., Amos B. HLA in two islands of French Polynesia. Tissue Antigens. 1984 Apr;23(4):217–228. doi: 10.1111/j.1399-0039.1984.tb00036.x. [DOI] [PubMed] [Google Scholar]
  8. Miniter P., Chan K. W., Pollack M. S., Dupont B., O'Neill G. J. HLA-linked genetic markers in Chinese and other Oriental populations. Tissue Antigens. 1981 Nov;18(5):285–298. doi: 10.1111/j.1399-0039.1981.tb01395.x. [DOI] [PubMed] [Google Scholar]
  9. Mittal K. K., Naik S., Sansonetti N., Cowherd R., Kumar R., Wong D. M. The HLA antigens in Indian Hindus. Tissue Antigens. 1982 Sep;20(3):223–226. doi: 10.1111/j.1399-0039.1982.tb00349.x. [DOI] [PubMed] [Google Scholar]
  10. Miyai K., Fukunishi T., Mizuta H., Amino N., Nose O., Tsuruhara T. HLA-A and -B antigens in Japanese patients with congenital hypothyroidism and their parents. Tissue Antigens. 1984 Apr;23(4):210–216. doi: 10.1111/j.1399-0039.1984.tb00035.x. [DOI] [PubMed] [Google Scholar]
  11. Moreno M. E., Kreisler J. M. HLA phenotype and haplotype frequencies in a sample of the Spanish population. Tissue Antigens. 1977 Feb;9(2):105–110. doi: 10.1111/j.1399-0039.1977.tb01089.x. [DOI] [PubMed] [Google Scholar]
  12. O'Neill G. J., Nerl C., Pollack M. S. Analysis of active and inactive complement C4 complotypes associated with subtypes of HLA-B17 in different racial groups. Am J Hum Genet. 1983 Mar;35(2):309–317. [PMC free article] [PubMed] [Google Scholar]
  13. Serjeantson S. W., Ryan D. P., Thompson A. R. The colonization of the Pacific: the story according to human leukocyte antigens. Am J Hum Genet. 1982 Nov;34(6):904–918. [PMC free article] [PubMed] [Google Scholar]
  14. de Mouzon A., Constans J., Sommer E., Sevin A., Quilici J. C., Fernet P., Ducos J., Ohayon E. HLA-a, B typing in Basque and other Pyrenean populations. Tissue Antigens. 1980 Jan;15(1):11–18. doi: 10.1111/j.1399-0039.1980.tb00879.x. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES