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. 1990 Sep;47(3):524–535.

Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports.

P McGuffin 1, M Sargeant 1, G Hetti 1, S Tidmarsh 1, S Whatley 1, R M Marchbanks 1
PMCID: PMC1683884  PMID: 2393025

Abstract

The report of a putative schizophrenia susceptibility gene linked to markers in the chromosome 5q11-q13 region and subsequent failures of replication have provoked considerable controversy. We here report six Welsh families multiply affected with schizophrenia in which there is no evidence for linkage between a dominant-like schizophrenia gene and 5q11-q13 markers. It is argued that our new results together with a combined reanalysis of previous studies suggest that a schizophrenia susceptibility gene can be excluded from the 5q11-q13 region. The apparent disparities between published results are most likely to reflect a chance finding in the one positive study and probably should not be interpreted as resulting from true linkage heterogeneity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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