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. 1986 Aug;39(2):239–244.

Geographical survey of βS-globin gene haplotypes: Evidence for an independent Asian origin of the sickle-cell mutation

A E Kulozik, J S Wainscoat, G R Serjeant, B C Kar, B Al-Awamy, G J F Essan, A G Falusi, S K Haque, A M Hilali, S Kate, W A E P Ranasinghe, D J Weatherall
PMCID: PMC1683923  PMID: 3752087

Abstract

The haplotypes of 152 βS-chromosomes were characterized in six different population groups. The chromosomes of individuals from Nigeria and from the southwest of the Arabian peninsula have the haplotype −−−−+ +−+ previously found in west African, Jamaican, and U.S. American blacks, whereas those from the eastern oases of Saudi Arabia and from the west and the east coast of India showed a different haplotype not found in Africa (++−++ ++−). These data are most consistent with an independent Asian origin of the sickle-cell mutation and provide further information about the geographic distribution of βS-haplotypes in the Old World. The distribution of the Asian βS-haplotype corresponds to the reported geographic distribution of a mild clinical phenotype of homozygous SS disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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