Abstract
Under the assumption of two family types, one with linkage and one without linkage, the number of phase-known double-backcross families required to detect heterogeneity is investigated. The case of testing for heterogeneity with two offspring per family is shown to be formally equivalent to testing for inbreeding effects in a sample of unrelated individuals.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cavalli-Sforza L. L., King M. C. Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data. Am J Hum Genet. 1986 May;38(5):599–616. [PMC free article] [PubMed] [Google Scholar]
- Haber M. Detection of inbreeding effects by the chi-square test on genotypic and phenotypic frequencies. Am J Hum Genet. 1980 Sep;32(5):754–760. [PMC free article] [PubMed] [Google Scholar]