Abstract
Automatic genotype elimination algorithms for a single locus play a central role in making likelihood computations on human pedigree data feasible. We present a simple algorithm that is fully efficient in pedigrees without loops. This algorithm can be easily coded and has been instrumental in greatly reducing computing times for pedigree analysis. A contrived counter-example demonstrates that some superfluous genotypes cannot be excluded for inbred pedigrees.
Full text
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Conneally P. M., Rivas M. L. Linkage analysis in man. Adv Hum Genet. 1980;10:209–266. doi: 10.1007/978-1-4615-8288-5_3. [DOI] [PubMed] [Google Scholar]
- Elston R. C. Segregation analysis. Adv Hum Genet. 1981;11:63-120, 372-3. doi: 10.1007/978-1-4615-8303-5_2. [DOI] [PubMed] [Google Scholar]
- Elston R. C., Stewart J. A general model for the genetic analysis of pedigree data. Hum Hered. 1971;21(6):523–542. doi: 10.1159/000152448. [DOI] [PubMed] [Google Scholar]
- Lange K., Boehnke M. Extensions to pedigree analysis. V. Optimal calculation of Mendelian likelihoods. Hum Hered. 1983;33(5):291–301. doi: 10.1159/000153393. [DOI] [PubMed] [Google Scholar]