Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1987 Jul;41(1):36–50.

Regionalization in hereditary IgA nephropathy.

R J Wyatt, M L Rivas, B A Julian, P A Quiggins, S Y Woodford, R G McMorrow, R W Baehler
PMCID: PMC1684172  PMID: 3605095

Abstract

The genealogies of 80 patients with IgA nephropathy who were born in central or eastern Kentucky or whose parents were born in this region were researched. At a minimum, 48 of these patients were related to at least one other patient. On the basis of presence or absence of established kinships, the patients were divided into three groups. Twenty-nine patients in group 1 belonged to one large pedigree. Their birthplaces and those of their parents, grandparents, and great-grandparents clustered in the extreme eastern portion of the state. Seventeen other patients, group 2, were related to at least one other patient but not to a patient in group 1. Their birthplaces and those of their ancestors did not show significant clustering. With the exception of two siblings, the 34 patients of group 3 had no family members with IgA nephropathy. The birthplaces for these patients and ancestors were widely scattered. These data suggest that one or more genetically determined factors are important in the pathogenesis of IgA nephropathy in some patients. A founder effect, whereby a gene(s) conveying susceptibility to IgA nephropathy was carried into eastern Kentucky by one or more of the early settlers, would explain the geographic clustering of the birthplaces of the patients in group 1 and their ancestors. The characteristic immunopathology of IgA nephropathy may represent the histologic result of separate disease processes, one or more of which could be genetically influenced.

Full text

PDF
36

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOWMAN H. S., MCKUSICK V. A., DRONAMRAJU K. R. PYRUVATE KINASE DEFICIENT HEMOLYTIC ANEMIA IN AN AMISH ISOLATE. Am J Hum Genet. 1965 Jan;17:1–8. [PMC free article] [PubMed] [Google Scholar]
  2. Berger J. IgA mesangial nephropathy 1968-1983. Contrib Nephrol. 1984;40:4–6. [PubMed] [Google Scholar]
  3. Berger J., Yaneva H., Crosnier J. La glomérulonéphrite à dépôts mésangiaux d'IgA: une cause fréquente d'insuffisance rénale terminale. Nouv Presse Med. 1980 Jan 19;9(4):219–221. [PubMed] [Google Scholar]
  4. Berthoux F. C., Gagne A., Sabatier J. C., Ducret F., Le Petit J. C., Marcellin M., Mercier B., Brizard C. P. HLA-Bw35 and mesangial IgA glomerulonephritis. N Engl J Med. 1978 May 4;298(18):1034–1035. doi: 10.1056/nejm197805042981825. [DOI] [PubMed] [Google Scholar]
  5. Beukhof J. R., Ockhuizen T., Halie L. M., Westra J., Beelen J. M., Donker A. J., Hoedemaeker P. J., van der Hem G. K. Subentities within adult primary IgA-nephropathy. Clin Nephrol. 1984 Oct;22(4):195–199. [PubMed] [Google Scholar]
  6. Clarkson A. R., Seymour A. E., Thompson A. J., Haynes W. D., Chan Y. L., Jackson B. IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol. 1977 Nov;8(5):459–471. [PubMed] [Google Scholar]
  7. D'Amico G., Imbasciati E., Barbiano Di Belgioioso G., Bertoli S., Fogazzi G., Ferrario F., Fellin G., Ragni A., Colasanti G., Minetti L. Idiopathic IgA mesangial nephropathy. Clinical and histological study of 374 patients. Medicine (Baltimore) 1985 Jan;64(1):49–60. [PubMed] [Google Scholar]
  8. Egido J., Blasco R., Sancho J., Lozano L., Gutierrez-Millet V. Immunological studies in a familial IgA nephropathy. Clin Exp Immunol. 1983 Nov;54(2):532–538. [PMC free article] [PubMed] [Google Scholar]
  9. Emancipator S. N., Gallo G. R., Lamm M. E. IgA nephropathy: perspectives on pathogenesis and classification. Clin Nephrol. 1985 Oct;24(4):161–179. [PubMed] [Google Scholar]
  10. Galla J. H., Kohaut E. C., Alexander R., Mestecky J. Racial difference in the prevalence of IgA-associated nephropathies. Lancet. 1984 Sep 1;2(8401):522–522. doi: 10.1016/s0140-6736(84)92599-6. [DOI] [PubMed] [Google Scholar]
  11. Hiki Y., Kobayashi Y., Tateno S., Sada M., Kashiwagi N. Strong association of HLA-DR4 with benign IgA nephropathy. Nephron. 1982;32(3):222–226. doi: 10.1159/000182849. [DOI] [PubMed] [Google Scholar]
  12. Jennette J. C., Wall S. D., Wilkman A. S. Low incidence of IgA nephropathy in blacks. Kidney Int. 1985 Dec;28(6):944–950. doi: 10.1038/ki.1985.222. [DOI] [PubMed] [Google Scholar]
  13. Julian B. A., Quiggins P. A., Thompson J. S., Woodford S. Y., Gleason K., Wyatt R. J. Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med. 1985 Jan 24;312(4):202–208. doi: 10.1056/NEJM198501243120403. [DOI] [PubMed] [Google Scholar]
  14. Kasahara M., Hamada K., Okuyama T., Ishikawa N., Ogasawara K., Ikeda H., Takenouchi T., Wakisaka A., Aizawa M., Kataoka Y. Role of HLA in IgA nephropathy. Clin Immunol Immunopathol. 1982 Nov;25(2):189–195. doi: 10.1016/0090-1229(82)90181-7. [DOI] [PubMed] [Google Scholar]
  15. Kashiwabara H., Shishido H., Tomura S., Tuchida H., Miyajima T. Strong association between IgA nephropathy and HLA-DR4 antigen. Kidney Int. 1982 Oct;22(4):377–382. doi: 10.1038/ki.1982.185. [DOI] [PubMed] [Google Scholar]
  16. Katz A., Karanicolas S., Falk J. A. Family study in IgA nephritis: the possible role of HLA antigens. Transplantation. 1980 Jun;29(6):505–506. doi: 10.1097/00007890-198006000-00016. [DOI] [PubMed] [Google Scholar]
  17. Laberge C. Hereditary tyrosinemia in a French Canadian isolate. Am J Hum Genet. 1969 Jan;21(1):36–45. [PMC free article] [PubMed] [Google Scholar]
  18. Le Petit J. C., Van Loghem E., De Lange G., Berthoux F. C., Chapuis-Cellier C., Serre J. L. GM, AM, PI and KM markers in mesangial IGA glomerulonephritis. J Immunogenet. 1981 Oct;8(5):415–418. [PubMed] [Google Scholar]
  19. MCKUSICK V. A., EGELAND J. A., ELDRIDGE R., KRUSEN D. E. DWARFISM IN THE AMISH I. THE ELLIS-VAN CREVELD SYNDROME. Bull Johns Hopkins Hosp. 1964 Oct;115:306–336. [PubMed] [Google Scholar]
  20. McCoy R. C., Abramowsky C. R., Tisher C. C. IgA nephropathy. Am J Pathol. 1974 Jul;76(1):123–144. [PMC free article] [PubMed] [Google Scholar]
  21. McLean R. H., Wyatt R. J., Julian B. A. Complement phenotypes in glomerulonephritis: increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Henoch-Schönlein purpura. Kidney Int. 1984 Dec;26(6):855–860. doi: 10.1038/ki.1984.228. [DOI] [PubMed] [Google Scholar]
  22. Montoliu J., Darnell A., Torras A., Ercilla G., Valles M., Revert L. Familial IgA nephropathy: report of two cases and brief review of the literature. Arch Intern Med. 1980 Oct;140(10):1374–1375. doi: 10.1001/archinte.140.10.1374. [DOI] [PubMed] [Google Scholar]
  23. Nomoto Y., Endoh M., Miura M., Suga T., Tomino Y., Sakai H., Nose Y., Tsuji K. IgA nephropathy associated with HLA-DR4 antigen. Am J Nephrol. 1984;4(3):184–187. doi: 10.1159/000166803. [DOI] [PubMed] [Google Scholar]
  24. Nomoto Y., Sakai H., Arimori S. Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Pathol. 1979 Feb;71(2):158–160. doi: 10.1093/ajcp/71.2.158. [DOI] [PubMed] [Google Scholar]
  25. Noël L. H., Descamps B., Jungers P., Bach J. F., Busson M., Suet C., Hors J., Dausset J. HLA antigen in three types of glomerulonephritis. Clin Immunol Immunopathol. 1978 May;10(1):19–23. doi: 10.1016/0090-1229(78)90004-1. [DOI] [PubMed] [Google Scholar]
  26. Richman A. V., Mahoney J. J., Fuller T. J. Higher prevalence of HLA-B12 in patients with IgA nephropathy. Ann Intern Med. 1979 Feb;90(2):201–201. doi: 10.7326/0003-4819-90-2-201. [DOI] [PubMed] [Google Scholar]
  27. Sabatier J. C., Genin C., Assenat H., Colon S., Ducret F., Berthoux F. C. Mesangial IgA glomerulonephritis in HLA-identical brothers. Clin Nephrol. 1979 Jan;11(1):35–38. [PubMed] [Google Scholar]
  28. Sakai H., Nomoto Y., Arimori S., Komori K., Inouye H., Tsuji K. Increase of IgA-bearing peripheral blood lymphocytes in families of patients with IgA nephropathy. Am J Clin Pathol. 1979 Sep;72(3):452–456. doi: 10.1093/ajcp/72.3.452. [DOI] [PubMed] [Google Scholar]
  29. Sakai H. T-cell function. Contrib Nephrol. 1984;40:124–129. doi: 10.1159/000409739. [DOI] [PubMed] [Google Scholar]
  30. Shirai T., Tomino Y., Sato M., Yoshiki T., Itoh T. IgA nephropathy: clinicopathology and immunopathology. Contrib Nephrol. 1978;9:88–100. doi: 10.1159/000401436. [DOI] [PubMed] [Google Scholar]
  31. Simon P., Ang K. S., Bavay P., Cloup C., Mignard J. P., Ramee M. P. Glomérulonéphrite à immunoglobulines A. Epidémiologie dans une population de 250 000 habitants. Presse Med. 1984 Feb 11;13(5):257–260. [PubMed] [Google Scholar]
  32. Sinniah R., Javier A. R., Ku G. The pathology of mesangial IgA nephritis with clinical correlation. Histopathology. 1981 Sep;5(5):469–490. doi: 10.1111/j.1365-2559.1981.tb01811.x. [DOI] [PubMed] [Google Scholar]
  33. Tolkoff-Rubin N. E., Cosimi A. B., Fuller T., Rublin R. H., Colvin R. B. IGA nephropathy in HLA-identical siblings. Transplantation. 1978 Dec;26(6):430–433. doi: 10.1097/00007890-197812000-00014. [DOI] [PubMed] [Google Scholar]
  34. Waldo F. B., Beischel L., West C. D. IgA synthesis by lymphocytes from patients with IgA nephropathy and their relatives. Kidney Int. 1986 Jun;29(6):1229–1233. doi: 10.1038/ki.1986.132. [DOI] [PubMed] [Google Scholar]
  35. Wyatt R. J., Julian B. A., Bhathena D. B., Mitchell B. L., Holland N. H., Malluche H. H. Iga nephropathy: presentation, clinical course, and prognosis in children and adults. Am J Kidney Dis. 1984 Sep;4(2):192–200. doi: 10.1016/s0272-6386(84)80071-2. [DOI] [PubMed] [Google Scholar]
  36. Wyatt R. J., Julian B. A., Weinstein A., Rothfield N. F., McLean R. H. Partial H (beta 1H) deficiency and glomerulonephritis in two families. J Clin Immunol. 1982 Apr;2(2):110–117. doi: 10.1007/BF00916894. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES