Abstract
Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hassold T. J., Jacobs P. A. Trisomy in man. Annu Rev Genet. 1984;18:69–97. doi: 10.1146/annurev.ge.18.120184.000441. [DOI] [PubMed] [Google Scholar]
- Hodge S. E., Anderson C. E., Neiswanger K., Sparkes R. S., Rimoin D. L. The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity. Am J Hum Genet. 1983 Nov;35(6):1139–1155. [PMC free article] [PubMed] [Google Scholar]
- Morton N. E., MacLean C. J., Lew R. Tests of hypotheses on recombination frequencies. Genet Res. 1985 Jun;45(3):279–286. doi: 10.1017/s0016672300022266. [DOI] [PubMed] [Google Scholar]
- Morton N. E., MacLean C. J. Multilocus recombination frequencies. Genet Res. 1984 Aug;44(1):99–107. doi: 10.1017/s0016672300026276. [DOI] [PubMed] [Google Scholar]
- Ott J., Linder D., McCaw B. K., Lovrien E. W., Hecht F. Estimating distances from the centromere by means of benign ovarian teratomas in man. Ann Hum Genet. 1976 Nov;40(2):191–196. doi: 10.1111/j.1469-1809.1976.tb00179.x. [DOI] [PubMed] [Google Scholar]
- Rao D. C., Morton N. E., Lindsten J., Hultén M., Yee S. A mapping function for man. Hum Hered. 1977;27(2):99–104. doi: 10.1159/000152856. [DOI] [PubMed] [Google Scholar]